ID   A0A2Y9KPS4_ENHLU        Unreviewed;       189 AA.
AC   A0A2Y9KPS4;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Interleukin-33 {ECO:0000256|ARBA:ARBA00016804};
GN   Name=LOC111156623 {ECO:0000313|RefSeq:XP_022373329.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022373329.1};
RN   [1] {ECO:0000313|RefSeq:XP_022373329.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022373329.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC       {ECO:0000256|ARBA:ARBA00004398}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. Highly divergent.
CC       {ECO:0000256|ARBA:ARBA00007933}.
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DR   RefSeq; XP_022373329.1; XM_022517621.1.
DR   AlphaFoldDB; A0A2Y9KPS4; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR026145; IL-33.
DR   PANTHER; PTHR21114; DVS27 PROTEIN; 1.
DR   PANTHER; PTHR21114:SF0; INTERLEUKIN-33; 1.
DR   Pfam; PF15095; IL33; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163}.
SQ   SEQUENCE   189 AA;  21653 MW;  3548D3AFDEC7E55B CRC64;
     MYFMQLRSGL IIEKTACYFR KEITKRHSPR TGISLFTEHS ASLSTYNDQS ITFVFEDGGY
     EIYVEDLRKD QEKDKVLFRY YDFQSPAHGT GDGVDGQTLL VNLSPTKDKD FLLHANNKEH
     SVELQKCENQ LPDQAFFRLH RKSSKCVSFE CKNNPGVFIG VKDNHLALIK VGDPSEDSKS
     IENTIFKLS
//