ID A0A2Y9KQ58_ENHLU Unreviewed; 797 AA.
AC A0A2Y9KQ58;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=LOC111157851 {ECO:0000313|RefSeq:XP_022375252.1,
GN ECO:0000313|RefSeq:XP_022375253.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022375253.1};
RN [1] {ECO:0000313|RefSeq:XP_022375252.1, ECO:0000313|RefSeq:XP_022375253.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022375252.1,
RC ECO:0000313|RefSeq:XP_022375253.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR RefSeq; XP_022375252.1; XM_022519544.1.
DR RefSeq; XP_022375253.1; XM_022519545.1.
DR STRING; 391180.A0A2Y9KQ58; -.
DR KEGG; elk:111157851; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF36; INTEGRIN BETA-7; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..797
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041069301"
FT TRANSMEM 726..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..92
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 50..476
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 645..721
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 746..792
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 51..61
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 54..91
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 64..80
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 216..223
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 271..311
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 412..428
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 448..688
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 474..478
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 488..500
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 497..537
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 502..511
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 513..527
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 543..548
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 545..574
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 550..559
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 561..566
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 580..585
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 582..613
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 587..596
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 598..605
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 619..624
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 621..666
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 626..635
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 638..641
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 645..654
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 797 AA; 86746 MW; 5C59C9CFB280B3AB CRC64;
MVALPVVLVF LLVLSRGESE LDAMISLSEK ATEWRDPDPS LQGSCQPASS CRECILSHPS
CAWCKQLNFT ASGLAEERRC GRRQELLARG CPLGELEEPR GRLEVLQDQP LSPGTRGEGA
TQLAPQRVRV TLRPGEPQQL RVRFLRAPGY PVDLYYLMDL SYSMKDDLER VRQLGHDLLV
QLQQVTHSVR IGFGSFVDKT VMPFVSTVSS KLRHPCPTRL ERCQPPFSFR HVLSLTGDAK
AFEREVGRQN VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
GGIFMPSDGH CHLDSDGLYR RSPEFDYPSV GQVAQALSAA NIQPIFAVTS ATLPVYQELS
KLIPKSAVGL LSEDSSNVVQ LIMDAYKSLS STVTLEHSPL PPGVHISYES QCGDPEKREG
EAGDRGQCNH VRTNQTVNFL VALQATHCSS EPQLLRLRAL GFSEELTVEV HTLCDCNCSD
TQPQAPHCSD GQGLLQCGVC SCAPGRLGRL CECSEAELSS PDLESGCRSP NGTGPLCSGK
GRCHCGRCSC SGQSSGSLCE CDDAGCERHE GILCGGFGRC RCGLCHCFAN RTGRACECSG
DTDSCTSPDG ILCSRHGQCR CNRCQCLEGY FGALCEQCPG CATSCERYRD CAECGAFGTG
PLALNCSGAC GSVNVTLTSA PILDDGWCKE RTLDNQLFFF LVEEGAGGKV VLRVRPKERA
DHTQTIVLGC VGGIVAVGLG LVLAYRLSVE IYDRREFRRF EKERHRLNWK QDSNPLYRSA
ITTTVNPRFQ EAGSPLL
//
