ID   A0A2Y9KQU9_ENHLU        Unreviewed;       950 AA.
AC   A0A2Y9KQU9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN   Name=LOC111155624 {ECO:0000313|RefSeq:XP_022371605.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022371605.1};
RN   [1] {ECO:0000313|RefSeq:XP_022371605.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022371605.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   RefSeq; XP_022371605.1; XM_022515897.1.
DR   AlphaFoldDB; A0A2Y9KQU9; -.
DR   STRING; 391180.A0A2Y9KQU9; -.
DR   KEGG; elk:111155624; -.
DR   OrthoDB; 2971005at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF7; NETRIN RECEPTOR UNC5C; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367033};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367033}.
FT   TRANSMEM        396..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   DOMAIN          175..256
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          549..692
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   950 AA;  105309 MW;  AED93D72A3C25485 CRC64;
     MRKGLLATAA RCGLGLGYVL QMLVLPALAL LSASGTGSAA QDDDFFHELP ETFPSDPPEP
     LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHIVDER VDETSGLIVR
     EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL
     EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP VEDRNFYITI DHNLIIKQAR LSDTANYTCV
     AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE
     GQSVQKIACT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK
     NCTDGLCMQS FLYPISTEQR TQNEYGFSSA PDSDDVALYV GIVIAVIVCL AISVVVALFV
     YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLVVPPD LTSAAAMYRG PVYALHDVSD
     KIPMTNSPIL DPLPNLKIKV YNTSGAVTPQ DDLSEFASKL SPQMTQSLLE NEALSVKNQS
     LARQTDPSCT AFGTFNSLGG HLIVPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKENMRPPM
     EDTQTLLTPV VSCGPPGALL TRPVILTMHH CADPNTEDWK IQLKNQAAQG QWEDVVVVGE
     ENFTTPCYIQ LDAEACHLLT ENLSTYALVG QSTTKAAAKR LKLAIFGPLC CSSLEYSVRV
     YCLDDTQDAL KEVLQLERQM GGQLLEEPKA LHFKGSTHNL RLSIHDIAHS LWKSKLLAKY
     QEIPFYHIWS GSQRNLHCTF TLERFSLNTV ELVCKLCVRQ VEGEGQIFQL NCTVSEEPTG
     IDLPLLDPAS TITTMTGPGA FSIPPPIRQK LCSSLDAPQT RGHDWRMLAH KLNLDRYLNY
     FATKSSPTGV ILDLWEAQNF PDGNLSMLAA VLEEMGRHET VVSLAAEGQY
//