ID A0A2Y9KS13_ENHLU Unreviewed; 453 AA.
AC A0A2Y9KS13;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Sex comb on midleg-like protein 4 isoform X1 {ECO:0000313|RefSeq:XP_022375948.1};
GN Name=LOC111158299 {ECO:0000313|RefSeq:XP_022375948.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022375948.1};
RN [1] {ECO:0000313|RefSeq:XP_022375948.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022375948.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR RefSeq; XP_022375948.1; XM_022520240.1.
DR AlphaFoldDB; A0A2Y9KS13; -.
DR STRING; 391180.A0A2Y9KS13; -.
DR KEGG; elk:111158299; -.
DR OrthoDB; 2908161at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR CDD; cd09578; SAM_Scm; 1.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR047531; SAM_Scm-like.
DR InterPro; IPR033763; SCML2_RBR.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF85; SEX COMB ON MIDLEG-LIKE PROTEIN 4; 1.
DR Pfam; PF17208; RBR; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 382..451
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 37..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 48826 MW; 794B50B66E55F9DE CRC64;
MPPSMAMPEC PALKPLRPAA PLLPVSDLSL PSVRLAPADM QSQRIPGRKR GRPPLHSTPM
KMAVHNLYSA SAGALPAVKI PKKRGRKPGY KLKSRVLMTP LALSPPRSTP EPDLSSIPQD
AATIPSLAAP QALTVCLYIN KQANAGPYLE RRKLQQLPEH FGPERPSVVL QQAVQACIDC
AHQQKLVFSL VKQGYGGEMV SVSASFDGKQ HLRSLPVVNS VGYVLRFLAK LCRSLLCDDL
FSHQPFSRGS SGSEEAQEKK DGRMESAKTA TTEECLANPV GMNRYSVDPS TSAFSHRGSF
PTSSSLYCKR QNSGDGHLGG GLATTANGPR SSPMSSGGPL APGLRPPGSS PKRNGTSLEG
NRCASSPSPN GPDARQPRSR NPSTWTVEDV VWFVKDADPQ ALGPHVELFR KHEIDGNALL
LLKSDMIMKY LGLKLGPALK LCYHIDKLKQ AKF
//
