ID A0A2Y9KSU3_ENHLU Unreviewed; 581 AA.
AC A0A2Y9KSU3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Protein disulfide-isomerase-like protein of the testis {ECO:0000313|RefSeq:XP_022372245.1};
GN Name=LOC111156009 {ECO:0000313|RefSeq:XP_022372245.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022372245.1};
RN [1] {ECO:0000313|RefSeq:XP_022372245.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022372245.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347}.
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DR RefSeq; XP_022372245.1; XM_022516537.1.
DR AlphaFoldDB; A0A2Y9KSU3; -.
DR STRING; 391180.A0A2Y9KSU3; -.
DR KEGG; elk:111156009; -.
DR OrthoDB; 5399045at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR CDD; cd02961; PDI_a_family; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02982; PDI_b'_family; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF58; PROTEIN DISULFIDE-ISOMERASE-LIKE PROTEIN OF THE TESTIS; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016073578"
FT DOMAIN 371..494
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 538..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 581 AA; 66930 MW; 82960169204974CB CRC64;
MKLLWMSLLL VAFCISTVRG LPEEDIKEAS INISQPMHIV EEGNLLVLTP AGLTQMLNQT
RFLMVLFHNP SSKQSRNLAE ELGQAVEVMG KGKNGIGFGK VDITVEKELQ KEFDVKKAPE
LKLFFEGNRS EPISCKGVVE STALVVWLRR QISQKAFLFN NTQQVVEFVN SRPLVIIGFF
QDLEEEVAEL FYDMIKDFPE LTFGVISISN VIGRFHVTLD SVLVFKKGKI VKREELINDI
TNKHVLNQVI KEHLTNFVIE YNTENKDLIY ELHILNHMLL FASKSWESFG LIMQHYKLAS
KEFTNKILFI LVNADEPRNG QILKYFRITE ANIPCVQILN LSSDARYKMP SEEITYENLK
KFGHSFLNRN AKKHQSSEDI PKYWDQGPVK QLVGKNFNVV VFDKERDVFV MFYAPWSEKC
KALFPVLEEL GRKYQNHSTV TIAKMDITAN DILLMYLDRY PFFRLFPINS QQAVLYTGEH
TLRGFSDFLE SQIKTRIEDE DEDELLSVEQ SEVTEEEALA EEKKVPFIKE ELPDQKLPEL
ENVTVPLEPA GLKETAEEEE KVAKPKGPPK QEKKPKVKEE L
//
