ID A0A2Y9KSW4_ENHLU Unreviewed; 158 AA.
AC A0A2Y9KSW4;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=GTP:AMP phosphotransferase AK3, mitochondrial-like {ECO:0000313|RefSeq:XP_022376836.1};
GN Name=LOC111158845 {ECO:0000313|RefSeq:XP_022376836.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376836.1};
RN [1] {ECO:0000313|RefSeq:XP_022376836.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022376836.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylate kinase family.
CC {ECO:0000256|RuleBase:RU003330}.
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DR RefSeq; XP_022376836.1; XM_022521128.1.
DR AlphaFoldDB; A0A2Y9KSW4; -.
DR STRING; 391180.A0A2Y9KSW4; -.
DR KEGG; elk:111158845; -.
DR OrthoDB; 5158396at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0004017; F:adenylate kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01428; ADK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00235; Adenylate_kinase_Adk; 1.
DR InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR InterPro; IPR007862; Adenylate_kinase_lid-dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23359:SF165; ADENYLATE KINASE ACTIVE SITE LID DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23359; NUCLEOTIDE KINASE; 1.
DR Pfam; PF00406; ADK; 2.
DR Pfam; PF05191; ADK_lid; 1.
DR PRINTS; PR00094; ADENYLTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003330};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003330}.
FT DOMAIN 89..123
FT /note="Adenylate kinase active site lid"
FT /evidence="ECO:0000259|Pfam:PF05191"
SQ SEQUENCE 158 AA; 17859 MW; 59E688D2272616CC CRC64;
MGARGRLLHA VLMGAPGSGK RTLASRMVKH FPLQKFSSGN PLRDNMLRDT GFPRTLRQAE
ALDRVYHIHL AMNMDVPVEV IRRRLSACWI HPSSGRVYNL EFHPPRAVGV DDLTGQPLVQ
QEDDRPETLT KRLKAYEDQT KRVLDCYRGK GVLETISG
//
