ID   A0A2Y9KT03_ENHLU        Unreviewed;       196 AA.
AC   A0A2Y9KT03;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Bcl-2-like protein 11 {ECO:0000256|PIRNR:PIRNR037827};
DE            Short=Bcl2-L-11 {ECO:0000256|PIRNR:PIRNR037827};
DE   AltName: Full=Bcl2-interacting mediator of cell death {ECO:0000256|PIRNR:PIRNR037827};
GN   Name=LOC111158508 {ECO:0000313|RefSeq:XP_022376288.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376288.1};
RN   [1] {ECO:0000313|RefSeq:XP_022376288.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022376288.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Induces apoptosis and anoikis.
CC       {ECO:0000256|PIRNR:PIRNR037827}.
CC   -!- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2
CC       proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
CC       {ECO:0000256|PIRNR:PIRNR037827}.
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC       {ECO:0000256|PIRNR:PIRNR037827}.
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DR   RefSeq; XP_022376288.1; XM_022520580.1.
DR   AlphaFoldDB; A0A2Y9KT03; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-UniRule.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:UniProtKB-UniRule.
DR   InterPro; IPR014771; Apoptosis_Bim_N.
DR   InterPro; IPR017288; Bcl-2-like_11.
DR   InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
DR   PANTHER; PTHR12044:SF9; BCL-2-LIKE PROTEIN 11; 1.
DR   PANTHER; PTHR12044; BCL2 INTERACTING MEDIATOR OF CELL DEATH; 1.
DR   Pfam; PF08945; Bclx_interact; 1.
DR   Pfam; PF06773; Bim_N; 1.
DR   PIRSF; PIRSF037827; Bcl-2-like_p11; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|PIRNR:PIRNR037827};
KW   Membrane {ECO:0000256|PIRNR:PIRNR037827};
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR037827};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          4..39
FT                   /note="Apoptosis Bim N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06773"
FT   DOMAIN          129..164
FT                   /note="Bcl-x interacting BH3"
FT                   /evidence="ECO:0000259|Pfam:PF08945"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   196 AA;  21936 MW;  B66C7D2965D6D338 CRC64;
     MAKQPSDVSS ECDREGGQLQ PVERPSQLRP GAPTSLQTEQ QGNPEGEGDR CPQGSPQGPL
     APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS PAPMSCDKST QTPSPPCQAF
     NHYLSAMASR RQSQAVPADM RPEMWIAQEL RRIGDEFNAY YPRRVFLNNY PAAEAHPQMI
     ILRLLRYIIR LVWRLQ
//