ID   A0A2Y9KT78_ENHLU        Unreviewed;      1029 AA.
AC   A0A2Y9KT78;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Semaphorin-6A isoform X1 {ECO:0000313|RefSeq:XP_022376956.1};
GN   Name=LOC111158918 {ECO:0000313|RefSeq:XP_022376956.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376956.1};
RN   [1] {ECO:0000313|RefSeq:XP_022376956.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022376956.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   RefSeq; XP_022376956.1; XM_022521248.1.
DR   AlphaFoldDB; A0A2Y9KT78; -.
DR   STRING; 391180.A0A2Y9KT78; -.
DR   KEGG; elk:111158918; -.
DR   OrthoDB; 5399685at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd11266; Sema_6A; 1.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF12; SEMAPHORIN-6A; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1029
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016083770"
FT   TRANSMEM        645..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..512
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   REGION          756..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          910..1029
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        913..956
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        969..1000
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1029 AA;  114216 MW;  6602339E2E9367EE CRC64;
     MRSEALLLYF TLLYFAGAGF PEDSEPISIS HGNYTKQYPV FVGHKPGRNT TQRHRLDIQM
     IMTMNRTLYV AARDHIYTVD MDTSHTEEIY CSKKLTWKSR QADVDTCRMK GKHKDECHNF
     IKVLLKKNDD TLFVCGTNAF NPSCRNYKMD TLEPSGDEFS GMARCPYDAK HANVALFADG
     KLYSATVTDF LAIDAVIYRS LGDSPTLRTV KHDSKWLKEP YFVQAVDYGD YIYFFFREIA
     VEYNTMGKVV FPRVAQVCKN DMGGSQRVLE KQWTSFLKAR LNCSVPGDSH FYFNILQAVT
     DVIRINGRDV VLATFSTPYN SIPGSAVCAY DMLDIANVFT GRFKEQKSPD STWTPVPDER
     VPKPRPGCCA GSSSLEKYTT SNEFPDDTLN FIKTHPLMDE AVPSVINRPW FLRTMVRYRL
     TKIAVDTAAG PYQNHTVVFL GSEKGIVLKF LARVGNSGFL NDSLFLEEMS VYNPEKCSYD
     GVEDKRIMGM QLDKASSSLY VAFSTCVIKL PLGRCERHGK CKKTCIASRD PYCGWVKEGG
     ACAHLSPSSR LTFEQDIERG STEGLGDCHN SFVALNGHSS SLLPSTTTSD TAAQEGYESR
     AGMLDWKDLL HSPDSTDSLG AVSSRNHQDK KGVIRESYLK GHDQLVPVTL LAIAVILAFV
     MGAVFSGIIV YCVCDHRRKD VSAVQRKEKE LTHSRRGSMS SVTKLSGLFG DTQSKDPKPE
     AILTPLMHNG KLATPGNTAK MLIKADQHHL DLAALPTPES TPTLQQKRKP SRGSREWERN
     QNLINACTKD MPPMGSPVIP TDLRASPSHI PSVVVLPITQ QSYQHEYVDQ PKMSEVAQMA
     LEDQAATLEY KTIKEHLSSK SPNHGVNLVE NLDSLPPKVP QREASLGPPG ASLSQNGLSK
     RLEMHHSSSY GLDYKRSYPT TNSLTRSHQA TTLKRNNTNC SNSSHLSRNQ SFGRGDNPPP
     APQRVDSIQV HGAQPSGQAV TVSRQPSLNA YNSLTRSGLK RTPSLKPDVP PKPSFAPLST
     SMKPNDACT
//