ID   A0A2Y9KVB9_ENHLU        Unreviewed;      1121 AA.
AC   A0A2Y9KVB9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-4 {ECO:0000313|RefSeq:XP_022377967.1};
GN   Name=LOC111159692 {ECO:0000313|RefSeq:XP_022377967.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022377967.1};
RN   [1] {ECO:0000313|RefSeq:XP_022377967.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022377967.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
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DR   RefSeq; XP_022377967.1; XM_022522259.1.
DR   AlphaFoldDB; A0A2Y9KVB9; -.
DR   STRING; 391180.A0A2Y9KVB9; -.
DR   KEGG; elk:111159692; -.
DR   OrthoDB; 2971287at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd01463; vWA_VGCC_like; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   PANTHER; PTHR10166:SF59; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-4; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF00092; VWA; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          274..456
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1121 AA;  125593 MW;  E121C88C60DDCBCE CRC64;
     MPGLPRFHPD TNAPHRGRPC CPWPVAPASL RKTTIMLGLL LSSTSLPPTH GQAKIPLETV
     KLWADTFGQD LYNTVTKYSG SLLLQKKYKD VEPSLSISEV DGLELVRKFS EDMEAMLRRK
     VEAVKNLVEA AEEADLNHEF NESLVFDYYN SVLINERDEN GNYVELGAEF ILESNTHFSN
     LMVNTSISNV QLPTNVYNKD PDILNGVYMS EALNPVFVEN FRRDPTLTWQ YFGSSTGFFR
     IYPGIKWTPD ENGVITFDCR NRGWYIQAAT SPKDIVIVVD TSGSMKGLRM TIAKHTISTI
     LDTLGENDFV NIITYSDYIH YIEPCFKGIL VQADRDNREH FKQLVDELMV KGVGVVNQAL
     IEAFQILKKF QEARQGSLCN QAIMLITDGA VEDYEPVFEK YNWPDRKVRV FTYLIGREVT
     FADRLKWIAC NNKGYYTQIS TLADAQENVM EYLHVLSRPM VINHDHDIIW TEAYMDSKLS
     TSQAQNMMLL TTVAMPVFSK KNETRSHGIL LGVVGSDVAL RELMKLAPRY KLGVHGYAFL
     NTNNGYILSH PDLRPLYREG KKLKPKPNYN SVDLSEVEWE DQAETLRTAM INGETGSLSM
     DVKVPLDKGK RVLFLTNDYF FTDISDTPFS LGVVLSRGHG EYILLGNTSV EDGLHDLLHP
     DLALASDWIY CITDIDPDHR KLSQLEAVVR FLTGEDPDLE CDEELVREVL LDAVVTAPME
     AYWTALALNA SDESEQVVDM AFLGTRAGLL RSTLFVGSEK VSDKKFLTPE DEASVFTLDG
     FPLWYRQAAE QPAGSFVFNL RSAEGAESPG QPMVVTASTA VAVTVDKKTA IAAAVGVQMR
     LEFLQRAFWA STRQCSPVDG PCPESCQDSE LDCFVIDNNG FILISGRSQE MGRFLGEVDG
     ALMTQLLSMG VFSQVTMYDY QAMCRPLSHH PSAARPLVSP ISALLTTARW LVNELVLVLL
     EWSAWGSWPA DSGAEAKAVF HHSHKHKKQD VLQPCDTEYP VFVHQTAIRE TNGIIECGAC
     QKIFVMQQIP NSNLLLLVTD PTCDCSIFPP VLQEATEVKY NASVKCDRLR SQKLRRRPDS
     CHAFHPEENA QECGGTSDTS ASLPMLLLPL CSWGLPPQLL R
//