ID A0A2Y9KWH6_ENHLU Unreviewed; 432 AA.
AC A0A2Y9KWH6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=LOC111158105 {ECO:0000313|RefSeq:XP_022375659.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022375659.1};
RN [1] {ECO:0000313|RefSeq:XP_022375659.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022375659.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022375659.1; XM_022519951.1.
DR AlphaFoldDB; A0A2Y9KWH6; -.
DR STRING; 391180.A0A2Y9KWH6; -.
DR KEGG; elk:111158105; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 69..377
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 73..221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 275..348
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 432 AA; 49798 MW; 9A5FE17F030D1A32 CRC64;
MERRRVTSAT RRSYASSLDV VGGGLVSGRR LGPGTRLSLA RMPLPLPARV DFSLAGALNT
GFKETRASER AEMMELNDRF ASYIEKVRFL EQQNKALAAE LNQLRAKEPT KLADVYQAEL
RELRLRLDQL TASSARLEVE RDNLAQDLGT LRQKLQDETN LRLDAENNLA TYRQEADEAT
LARLDLERKI ESLEEEIQFL RKIHEEEVQE LQEQLARQQV HVELDVAKPD LTAALREIRT
QYEAMASSNM HEAEEWYRSK FADLNDAAAR NAELLRQAKH EANDYRRQLQ ALTCDLESLR
GTNESLERQM REQEERHARE AASYQESLAR LEEEGQSLKD EMARHLQEYQ DLLNIKLALD
IEIATYRKLL EGEENRITIP VQTFSNLQIR ETSLDTKSVS EGHLKRNIVV KTVEMRDGEV
IKESKQEHKD VM
//
