ID A0A2Y9KXT1_ENHLU Unreviewed; 1328 AA.
AC A0A2Y9KXT1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Niemann-Pick C1-like protein 1 {ECO:0000313|RefSeq:XP_022373985.1};
GN Name=LOC111157060 {ECO:0000313|RefSeq:XP_022373985.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022373985.1};
RN [1] {ECO:0000313|RefSeq:XP_022373985.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022373985.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR RefSeq; XP_022373985.1; XM_022518277.1.
DR STRING; 391180.A0A2Y9KXT1; -.
DR KEGG; elk:111157060; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF3; NPC1-LIKE INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1328
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015846626"
FT TRANSMEM 278..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1114..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1207..1231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1243..1266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 633..798
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1328 AA; 144858 MW; 99DEE9D4941E2C3A CRC64;
MAEAGPRSWL LWALLLHLAQ GKPHTPIHRP GYCAFYEECG RNPELSGGLA PLSNVSCLSN
TPAVLVTGNH LNLLRRICPR LYSGPNSTYA CCSSKQLVSL EASLAVTKAL LTRCPACSDN
FVNLHCLNTC SPNQSLFINV TRVVGGGGGR PPAVVAYEAF YQQNFAQRTY DSCSRVRIPA
AATLAVGAMC GVYGSALCTA QRWLNFQGDT GNGLAPVDIT FHLLEPGQDP GSGLQPLNGE
VQPCNVSQGN GTAACSCQDC AASCPVIARP QALDATFYLG QMAGGLVLVI LLCSALVLLT
AFLVATRLAA SHRRDKTPDP KAGASLSDRL SLSTHTVLSR CFQAWGTWVA SWPLTVLLLS
IAVVVALSGG LAFVQLTTDP VELWSAPSSQ ARSEKAFHDQ HFGPFFRTNQ VILTAPGEPG
YHYDSLLLGP KNFSGILALD FLLELLELQE RLRHLQVWSP TEKRNISLQD VCFAPLNPHS
TRLSDCCVNS ILQYFQSNRS RLLLTANQTL TGQTSQVDWR DHFLYCVNAP LTFKDGTALA
LSCMADYGGP VFPFLAVGGY KGKDYSEAEA LIMTFSLNNY EPGDPRLAQV KLWEAAFLEE
MKAFQRQTAG RIQVTFMAER SLEDEINRTT AQDLPIFGVS YIIIFLYISL ALGSYSSWRR
VLVDSKVTLG LGGVAVVLGA VTAAMGFFSY LGVPSSLVIL QVVPFLVLAV GADNIFIFVL
EYQRLPRRPE ERREAHIGRA LGRVAPSMLL CSLSEAICFF LGALTPMPAV RTFALTSGFA
IVLDFLLQVS AFVALLSLDS RRQEASRLDV CCCVGAPKLP PPDQSEGLLL WFFRKFYVPL
LLHRVTHGVV LLLFTGLFGV GLYFMCHISV GLDQELALPK DSYLLDYFFS LNRYFEVGAP
VYFVTTGGYN FSSEAGMNAI CSSAGCDSYS LTQKIQYASE FPEESYLAIP ASSWVDDFID
WLTPSPCCRL YIYGPNKGEF CPSTVNSLAC LKNCMSLTLG PVRPSEEQFQ KYLPWFLSDP
PNVKCPKGGL AAYNTSVHLG HDGQILASRF MAYHKPLRNS QDYTEALRAS RALAANITAY
LRQVPGTDPA FEVFPYTITN VFYEQYLNVV PEGLFMLAIC LLPTFIVCCL LLGMDLRSGF
LNLFSIIMIL VDTVGFMALW GISYNAVSLI NLVTAVGISV EFVSHITRAF AVSTRPTRLE
RAKEATVFMG SAVFAGVAMT NLPGILVLGL AKAQLIQIFF FRLNLLITVL GLLHGLVLLP
VVLSYLGPDV NAALVLEQKQ MEEATRVRMA SCPSHPGPTS TSSSTYVNYG FEHSSKSGLH
SSLPRSGH
//
