ID   A0A2Y9KY59_ENHLU        Unreviewed;       166 AA.
AC   A0A2Y9KY59;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
GN   Name=LOC111158494 {ECO:0000313|RefSeq:XP_022376259.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376259.1};
RN   [1] {ECO:0000313|RefSeq:XP_022376259.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022376259.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU003753}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC       ECO:0000256|RuleBase:RU003753}.
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DR   RefSeq; XP_022376259.1; XM_022520551.1.
DR   AlphaFoldDB; A0A2Y9KY59; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10078:SF27; INTERLEUKIN-36 GAMMA; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01359; INTRLEUKIN1B.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SMART; SM00125; IL1; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU003753}.
SQ   SEQUENCE   166 AA;  18453 MW;  134F9C3346136701 CRC64;
     MTCIRGIPIS GEPLSAVNQP HTGEVSDLNQ QVWVLQGQTI VTVPRSNSVN PVTVTVVPCK
     YPESLEQGRG VPIYLGIENP EMCLSCEDIE GQPTLQLKEE KILRLYNEVE PVDPFLFYRL
     EIHSTSTFES VAFPGWFIAS SDRGHPIFLT SHQGQNNVNF NLSINA
//