ID A0A2Y9KY91_ENHLU Unreviewed; 495 AA.
AC A0A2Y9KY91;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tripartite motif-containing protein 65 isoform X2 {ECO:0000313|RefSeq:XP_022379052.1};
GN Name=LOC111160326 {ECO:0000313|RefSeq:XP_022379052.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379052.1};
RN [1] {ECO:0000313|RefSeq:XP_022379052.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379052.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022379052.1; XM_022523344.1.
DR AlphaFoldDB; A0A2Y9KY91; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19835; Bbox2_TRIM65_C-IV; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF29; TRIPARTITE MOTIF-CONTAINING PROTEIN 65; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 12..51
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 289..482
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 136..231
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 495 AA; 55318 MW; 196AF0277519E9DB CRC64;
MTAPRLEDVL TCSICLGLYV EPVTLSCGHN FCGACIGDWG RGCDKACPEC RKPFPDGAEL
RRNVALSAVL EAMRVGPGPD SAPASGSALG ARCPRHGRPL DLFCRTEARC ICSACTVNEC
LLHERALLDD ERREREAQLR ATLEVSQQQV TQVERQLEEL RQQSSQIQTS ACTLASVISG
KFSRLLQALE MRRALALKDI KVAETQALAQ AQDAEQRLRG HREALVRYDR RVRDLLQQLD
DCTFLQESQL LAPPAPLGPL TPLKLDEDQQ LAGLKESLSQ LCGLLLEEGD RPRAPAEAAD
SGPMDYRNLT FDPDSANRHL YVSRQDQQVK HQHKPRDPAG PSSFELWQVR CAQSFQNGRH
YWEVHTSNHS VTLGVAYPDL TRRKWGPHTD NIGRGPSSWG LCVQEDRAQA WHNGEAQLLP
KVSGRLLGME LDLVSGCLTF YCLEPRAQRL HTFHAIFTQP LYPVFWLLEG RTLTLCHRPE
ARLPSELQEE ASEPS
//
