ID A0A2Y9KZT3_ENHLU Unreviewed; 413 AA.
AC A0A2Y9KZT3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rhomboid domain-containing protein 3 isoform X1 {ECO:0000313|RefSeq:XP_022378603.1};
GN Name=LOC111160079 {ECO:0000313|RefSeq:XP_022378603.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022378603.1};
RN [1] {ECO:0000313|RefSeq:XP_022378603.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022378603.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_022378603.1; XM_022522895.1.
DR AlphaFoldDB; A0A2Y9KZT3; -.
DR STRING; 391180.A0A2Y9KZT3; -.
DR KEGG; elk:111160079; -.
DR OrthoDB; 4642509at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR43066:SF16; RHOMBOID DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR43066; RHOMBOID-RELATED PROTEIN; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR Pfam; PF00627; UBA; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..178
FT /note="Peptidase S54 rhomboid"
FT /evidence="ECO:0000259|Pfam:PF01694"
FT DOMAIN 353..386
FT /note="UBA"
FT /evidence="ECO:0000259|Pfam:PF00627"
FT REGION 203..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 42345 MW; 7716113FC63102F3 CRC64;
MRAQGPLSLP SLTLPLASSV LMLLLGSLWL VGAGPSLALA PELLLDPWQA HRLLTHALGH
TALPGLLLSL LLLPTLGWWQ ECHLGTLRFL HASALLALAA GLMGVLLAGL GVSSAAGGCG
YMPVHLAMLA GQGHHPRQPQ GVLPPWLLPW LLLALTPLLS SEPPFLQLFC GLLAGLAYRC
SRGLPVAGAV RAAAASTAGG RLVQGTGRGL ATPTPSYPRH PSRAAAHPSC RSEVSTVLKT
PLVAAVAGAG SQALFCFCPS RPPTPGPPYM ASPSLWALSE GSALLPPGLG PVQPAWEGSS
EVGLAWAGPS FPPGTPLWAA LDEQLLQEGI EASLLEGPRP ESPLRLPKSS VSSLRLQQLE
RMGFPTEQAV VALAATGRVE GAVSLLVGGE VGTEALVTQG RGGPAHPEGP GPP
//
