ID A0A2Y9KZZ6_ENHLU Unreviewed; 487 AA.
AC A0A2Y9KZZ6;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Nectin-2 isoform X2 {ECO:0000313|RefSeq:XP_022379647.1};
GN Name=LOC111160672 {ECO:0000313|RefSeq:XP_022379647.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379647.1};
RN [1] {ECO:0000313|RefSeq:XP_022379647.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379647.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022379647.1; XM_022523939.1.
DR AlphaFoldDB; A0A2Y9KZZ6; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd20930; Ig3_Nectin-5_like; 1.
DR CDD; cd07703; IgC1_2_Nectin-2_Necl-5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR47387; NECTIN-2; 1.
DR PANTHER; PTHR47387:SF1; NECTIN-2; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..487
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015872566"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..160
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 168..262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 267..352
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 397..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 51963 MW; 4D67186F02ACB60C CRC64;
MARAAALPPS RSSPTLPLLP LLLLLLLHLL RETGAQDVQV RVPPEVRGYL GSTVQLPCHL
LPPGPEVRVS QVTWLHVDAA GVSKSVAAFH PSYGPSFRSP KPGEERLSFV TAGQSAGTRQ
GTEMDLRDAT LALRGLTVDD EGNYTCEFAT FPSGTSRGVT WLKAIAQPQN HAETQEVTLS
LEPVPVARCV SEGGRPPARI SWFSPLDGET KETQMSGPVP GTVTVTSRFT LVPLSRADGV
KVTCKVEHES FEEPILLPVT LSVRYPPEVS ISGYDDNWYL GRSEATLSCD VRSKPEPTGY
DWSTTAGIFP ASAIAQGPQL IIHSVDRLVN TTFICTVTNA VGTGRAEQVV LVRDTPRASP
RDVGPVVWGA VGGTLLVLLL LAGGSLAFIL LRVRRRRKSP GGGGGGGESS GGGAYDPKTQ
VFGNGGPVFW TPAAPGPLKP DGKEEEDEEE EEEKAEEGLM LPPPKALEDD MESQLDGSLI
SRRAIYV
//
