ID A0A2Y9L010_ENHLU Unreviewed; 470 AA.
AC A0A2Y9L010;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=ADAM DEC1 {ECO:0000313|RefSeq:XP_022374760.1};
GN Name=LOC111157544 {ECO:0000313|RefSeq:XP_022374760.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022374760.1};
RN [1] {ECO:0000313|RefSeq:XP_022374760.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022374760.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR RefSeq; XP_022374760.1; XM_022519052.1.
DR AlphaFoldDB; A0A2Y9L010; -.
DR STRING; 391180.A0A2Y9L010; -.
DR KEGG; elk:111157544; -.
DR OrthoDB; 5406290at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF125; ADAM DEC1; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00276}; Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..470
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015868156"
FT DOMAIN 217..412
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 420..460
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT ACT_SITE 353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 369..374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 470 AA; 52795 MW; 12F39441F440C161 CRC64;
MLCGTSQLSA VGNMSLALLS VLWLIIQTQA IAINQTSELE LYEVVHPKKL HILHKREIRN
NQTENGKEER YEPELQYQIT LNGEEVVLHL QKSKHILRPD YSEIYYSPRG EEITTDPQNM
EHCFYKGHIL NEKGSVASIS TCNGLRGYFT HHDQRYMIKP LKSTDQEEHA VLTYNQEEPD
LANYTCGVRS VGRKQGHIRT SRSLNSPEEK NYLQAEKYID LLLVLDNAFY NMYKGNLTLI
RSFVFDVMNL LNVIYNTIDV QVALVGMEIW SDGDKIKIVP NIGDTFNNFL NWHRSNLGKM
KRHDHAQLLS GIGFSNRRVG MAASNSLCSS ASVAVIEASG KNNVALVGVM SHELGHVLGM
PDVPYYTKCP SGSCVMNEYL SSKFPKDFSI SCRSHFKKYI LSQKPKCLLQ APTPKNIITN
SVCGNKLLEA GEDCNCGSPK ECSNRCCEAV TCTLKPEAGC KGDTLNNITQ
//
