ID A0A2Y9L069_ENHLU Unreviewed; 1153 AA.
AC A0A2Y9L069;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Proto-oncogene DBL isoform X5 {ECO:0000313|RefSeq:XP_022376994.1};
GN Name=LOC111158943 {ECO:0000313|RefSeq:XP_022376994.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376994.1};
RN [1] {ECO:0000313|RefSeq:XP_022376994.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022376994.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022376994.1; XM_022521286.1.
DR AlphaFoldDB; A0A2Y9L069; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 27..227
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 648..828
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 846..962
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1069..1130
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 383..413
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 973..1002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1153 AA; 131937 MW; D4F7079C2EA204FA CRC64;
MAAAGSGPHL GSPTLAAPDA RPASAPPAPV RCGGTPGLLV GRDRYASVPA AQAAPLQVDV
AVALPRGRSS EKYGRSYLCL LQAVFVAGGR GKENDWIITF PENCNFRCIP EEVIAKVLTY
LTSIARQNGS DSRFTIILDR RLDTWSSLKI SLQKISVSFP GNLHLVLVLR PTSFLQRTFT
DIGFRFSQED FMLKLPVVML SSVSDLLTYI DDKQLTPELG GTLQYCHSEW IIFRNAIENF
ALTVKEMAQM LQSFGTELAE TELPDDIPSI EEILAVRAER YHMLKNDITA VTKEGKILLT
SLEVPGAEDP VGSRLEHRHH VNGDWQTVNK LLTQVHDMEI AFDGFWEKHQ LKMQQYLQLW
KFEQDFQELV SEVELMLNQQ AELADVTGNI GQVKQKIKKL ENLDENSQDL LAKARFVILH
GHRLAANHHY ALDLICQRCN ELRYLSDVLV KEIKAKRIQL SKIFKMHKLL QQARQCCDEG
ECLLANQEID KFQSKEDAQK ALRDIENFLE MALPFINYDP DTLQYEFDVI LSPELKVQMQ
TVQLKLEHIR SAFENQQAGF RNLTDKNMKP VEFVVPASDN LMRSRATFSP KHVGVGYSFF
QACKLFSKGK KTWRQNQSDL KIEVVHDGRE KSSDQSSSLD NDNTLDVLQN HVLNELIQTE
RVYVRELFTV LLGYRAEMDN PEMFDLMPPL LRNKKDVLFG NMAEIYEFHN NIFLNSLENC
VDAPERVGPC FLERKDDFQM YAKYCQNKPR SEAIWKKYSE CAFFQECQRK LKHRLGLDSY
LLKPVQRITK YQLLLKELLK YSKGCRGFEQ LKEALDTMLD LLKSVNDSMH QIAINGYIGN
LNELGKMIMQ GAFSVWTGHK KGATKMKDFA RFKPMQRHLF LYEKAIVFCK RRVESGEGSE
RYPSYSFKHC LKMDEVGITE YVKGDNRKFE IWYAGKEEVY IVQAPNVDVK MTWLKEIRNI
LLKQQELMTV KKRKQHNPLT DLDHLSSQRN DENPKRRQHG SFLGAEEPVP EPSGALAEVQ
EAVPLVRAEA NTGWTQMSAP AEISEDPEEW PSNYVYASYD DNEEIRPLMS PGKYKALADC
RKRGPEDLLI RNGDVIQFLH EDVEGQWLVK NLNRRKEGLI PGNTAQVLIG DYRFRNAKVP
DAALSNTRKL SSP
//