ID A0A2Y9L106_ENHLU Unreviewed; 366 AA.
AC A0A2Y9L106;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=LIM and senescent cell antigen-like-containing domain protein {ECO:0000256|PIRNR:PIRNR038003};
GN Name=LOC111160883 {ECO:0000313|RefSeq:XP_022379987.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379987.1};
RN [1] {ECO:0000313|RefSeq:XP_022379987.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379987.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Adapter protein in a cytoplasmic complex linking beta-
CC integrins to the actin cytoskeleton, bridges the complex to cell
CC surface receptor tyrosine kinases and growth factor receptors.
CC {ECO:0000256|PIRNR:PIRNR038003}.
CC -!- SUBUNIT: Part of the heterotrimeric IPP complex composed of integrin-
CC linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
CC {ECO:0000256|PIRNR:PIRNR038003}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|PIRNR:PIRNR038003}. Cell membrane
CC {ECO:0000256|PIRNR:PIRNR038003}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR038003}.
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DR RefSeq; XP_022379987.1; XM_022524279.1.
DR AlphaFoldDB; A0A2Y9L106; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd09331; LIM1_PINCH; 1.
DR CDD; cd09332; LIM2_PINCH; 1.
DR CDD; cd09333; LIM3_PINCH; 1.
DR CDD; cd09334; LIM4_PINCH; 1.
DR CDD; cd09335; LIM5_PINCH; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR InterPro; IPR047944; LIMS1/2-like_LIM1.
DR InterPro; IPR047946; PINCH-1/2-like.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24210:SF10; LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2; 1.
DR PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00412; LIM; 5.
DR PIRSF; PIRSF038003; PINCH; 1.
DR SMART; SM00132; LIM; 5.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE 4: Predicted;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038003};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038003};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR038003};
KW Membrane {ECO:0000256|PIRNR:PIRNR038003};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 38..99
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 101..158
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 221..280
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 281..340
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 366 AA; 41416 MW; 90B4F3FC0BB3B960 CRC64;
MAARLGALAA SGLYRRRQHR QSPPPAALGN MSNALANAVC QRCQARFAPA ERIVNSNGEL
YHEHCFVCAQ CFRPFPEGLF YEFEGRKYCE HDFQMLFAPC CGSCGEFIIG RVIKAMNNNW
HPGCFRCELC DVELADLGFV KNAGRHLCRP CHNREKAKGL GKYVCQRCHL VIDEQPLMFK
NDAYHADHFS CTHCGKELTA EARELKGELY CLPCHDKMGV PICGACRRPI EGRVVNALGK
QWHVEHFVCA KCEKPFLGHR HYEKKGLAYC ETHYNQLFGD VCYNCSHVIE GDVVSALNKA
WCVNCFSCST CNSKLTLKNK FVEFDMKPVC KRCYEKFPLE LKKRLKKLSE LAARKAPPKS
VGLNSA
//
