ID A0A2Y9L148_ENHLU Unreviewed; 543 AA.
AC A0A2Y9L148;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nectin-2 isoform X1 {ECO:0000313|RefSeq:XP_022379646.1};
GN Name=LOC111160672 {ECO:0000313|RefSeq:XP_022379646.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379646.1};
RN [1] {ECO:0000313|RefSeq:XP_022379646.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379646.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022379646.1; XM_022523938.1.
DR AlphaFoldDB; A0A2Y9L148; -.
DR STRING; 391180.A0A2Y9L148; -.
DR KEGG; elk:111160672; -.
DR OrthoDB; 5358399at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd20930; Ig3_Nectin-5_like; 1.
DR CDD; cd07703; IgC1_2_Nectin-2_Necl-5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR47387; NECTIN-2; 1.
DR PANTHER; PTHR47387:SF1; NECTIN-2; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..543
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016073581"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..160
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 168..262
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 267..352
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 396..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 58276 MW; 7C15E6CEA5236080 CRC64;
MARAAALPPS RSSPTLPLLP LLLLLLLHLL RETGAQDVQV RVPPEVRGYL GSTVQLPCHL
LPPGPEVRVS QVTWLHVDAA GVSKSVAAFH PSYGPSFRSP KPGEERLSFV TAGQSAGTRQ
GTEMDLRDAT LALRGLTVDD EGNYTCEFAT FPSGTSRGVT WLKAIAQPQN HAETQEVTLS
LEPVPVARCV SEGGRPPARI SWFSPLDGET KETQMSGPVP GTVTVTSRFT LVPLSRADGV
KVTCKVEHES FEEPILLPVT LSVRYPPEVS ISGYDDNWYL GRSEATLSCD VRSKPEPTGY
DWSTTAGIFP ASAIAQGPQL IIHSVDRLVN TTFICTVTNA VGTGRAEQVV LVRETPNTAG
AGATGGIIGG IIAAIIATAV VATGILICRQ QRKEQRLQGA EEEDDLEGPP SYKPPTPKAK
LEEPEMPSQL FTLGASEHSP LKTPYFDAGV SCAEQDMPRY HELPTLEERS GPLLLGATGL
GSPILVPPGP PVMEGVSLDL EDDDEEEEDY LDKINPIYDA LSYSSPSDSY QSKGFVMSRA
MYV
//
