ID A0A2Y9L1M9_ENHLU Unreviewed; 515 AA.
AC A0A2Y9L1M9;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Forkhead box protein O4 isoform X1 {ECO:0000313|RefSeq:XP_022380197.1};
GN Name=LOC111161038 {ECO:0000313|RefSeq:XP_022380197.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022380197.1};
RN [1] {ECO:0000313|RefSeq:XP_022380197.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022380197.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR RefSeq; XP_022380197.1; XM_022524489.1.
DR AlphaFoldDB; A0A2Y9L1M9; -.
DR STRING; 391180.A0A2Y9L1M9; -.
DR KEGG; elk:111161038; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20062; FH_FOXO4; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047409; FH_FOXO4.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF3; FORKHEAD BOX PROTEIN O4; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 104..198
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 104..198
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 54594 MW; A351AC4F4760DC52 CRC64;
MDPRNENSAT EAAAIIDLDP DFEPQSRPRS CTWPLPRPEI STETAEPPEP PEVEPGLGDK
VLTEGHSEPT LLPSQLPEPA GGPQPGILGA VTGPRKGGSR RNAWGNQSYA ELISQAIESA
PEKRLTLAQI YEWMVRTVPY FKDKGDSNSS AGWKNSIRHN LSLHSKFIKV HNEATGKSSW
WMLNPEGGKS GKAPRRRAAS MDSSSKLLRG RSKAPKKKPA VLPAPPEGAT PTSPVGHFAK
WSGSPCSRNR EEADVWTTFR PRSSSNASTV STRHSPMRPE SEVLAEGEMP ASVSSYAGGV
PPTLNEDLEL LDGLNLTSSH SLLSRSSLSG FSLQHPGGTG PLHTYSTSLF SPAEGPLAAG
EGCFASSQSL EALLTSDTPP PPSDVLMTQV DPILSQAPTL LLLGGLPSSS KLATGVGLCP
KPLEAPGPSG LVPTLSMIAP PSVMAGAPIP KPLGAPVLTP STEAAGQDRM PQDLDLDMYM
ENLECDMDNI ISDLMDGGEG LDFNFEPGRT PLRPQ
//
