ID A0A2Y9L336_ENHLU Unreviewed; 474 AA.
AC A0A2Y9L336;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Izumo sperm-egg fusion protein 1 {ECO:0000313|RefSeq:XP_022379788.1};
GN Name=LOC111160749 {ECO:0000313|RefSeq:XP_022379788.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379788.1};
RN [1] {ECO:0000313|RefSeq:XP_022379788.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379788.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Izumo family.
CC {ECO:0000256|ARBA:ARBA00009633}.
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DR RefSeq; XP_022379788.1; XM_022524080.1.
DR AlphaFoldDB; A0A2Y9L336; -.
DR STRING; 391180.A0A2Y9L336; -.
DR KEGG; elk:111160749; -.
DR OrthoDB; 4610439at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR GO; GO:0035036; P:sperm-egg recognition; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR029389; IZUMO.
DR InterPro; IPR032699; Izumo-Ig.
DR InterPro; IPR032700; IZUMO1.
DR PANTHER; PTHR35540; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR PANTHER; PTHR35540:SF1; IZUMO SPERM-EGG FUSION PROTEIN 1; 1.
DR Pfam; PF15005; IZUMO; 2.
DR Pfam; PF16706; Izumo-Ig; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..474
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016050622"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..367
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT REGION 375..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 52269 MW; 5BCBA096A1981839 CRC64;
MGPQLPFLVA ALAVCLLPAR ACLMCATKVV EALDSLEKTY LPDHLPAERH ESFMKRVKEA
VLDFKNLPIQ EDSYMGVVDE PTLENASWSF LKDLKRITDS NVEGELFVKE MFWMLHLQKG
IFARFAAQFQ KEVFCPNQCG ESEFGSWSLS LMVAPVIPSR SPPSLGLDVS PFSTSERFHS
PFALRAYWRA RHIVFTLFTE PGSIPLPAGL PSTPAPWADL PGIGHLTPPQ PLALPSPFSL
VPQGEYSVDT APSGVMLQSL IWCNSCERQV HACRKTANCG ERVVLVHEKE DMILNCELNW
HRLSQGLTNY SFFRVWGQNS ETLLSEGKDP ILTKTAVTAE DAGVYRCRLG TVRSIPATIL
FFRVTVLPER ISEELPSSQA GEAAGPGDSG SLQRPPAGQP TSTQCPKSEN MLRGRLIGLL
IWGFVVLIIG FATAILCFRP ERVINCIKDC LGTMKESATP PQISKEKATS SGHK
//
