ID A0A2Y9L4D0_ENHLU Unreviewed; 1367 AA.
AC A0A2Y9L4D0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 1 {ECO:0000313|RefSeq:XP_022380218.1};
GN Name=LOC111161052 {ECO:0000313|RefSeq:XP_022380218.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022380218.1};
RN [1] {ECO:0000313|RefSeq:XP_022380218.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022380218.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_022380218.1; XM_022524510.1.
DR STRING; 391180.A0A2Y9L4D0; -.
DR KEGG; elk:111161052; -.
DR OrthoDB; 338452at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 293..602
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 973..1255
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1265..1354
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 157..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 153534 MW; 57173BFC88E0B277 CRC64;
MASGVEWRLA RYLDVLEKEE LKDFQLRLPE KPLGGPPLRL SLACGQQPGG LEVASQLVAQ
YGEQQAWDLA LHTWEQMGLS QLCAQAREEA ALMPAEYSWL PCSPSAPSMQ SPSGPTSTKV
LSFVQDPPTG SWRQLRGKFR RSLQNRGLIL PFYQSLSSSP DQKSPLQESP SAPTSTAVLE
DSVHPSWPRH KPRKQEAPRA EWLLIETSGE HSRGIGERRQ HQERKRPCPT KSWRNEDLHE
EFVELLLLHQ SHRRLQESQS KGSWHHSRVE KQGQLIKVKD LFGPGLGAQE EGRTVVLHGV
AGVGKSVVAR QLRRAWEEGR LYRNRFQHVF YFSCRQLAQS TTMSLKELIT KDWAAPTAPS
EQILSHPGQL LLILDGLDEL KWVLGKEKSE VCPYWDQPQL VKTLLGGLLR KTILPGASLL
ITARTTALHL FILSVEQPRW VKVLGFSKSG RKEYFYKYFK SESKAYRAFC AVELNQPLLT
MCLVPLVSWL VCTCMKKKLE QGESLWLPSQ TTTALCLHYL AQALPAQPLG TQLRGLCSLA
AKGVRQGESL LIWEDLRKHE LEEATVSALL EMGILRKHPS SPDYDFAHQY LQEFFAAVSC
VLESEDKECH PPDSIRGLED LLKAYGGLAP FGAPTTCFIL GLLSEQVQRE MEAIFQGKVP
AERKRRLLCW AEEAVRNQLP ILQQGSLPML HCLYETQDKD FLTRVMAPFH GASVRVHTGL
ELLVFMFCIK FCAVKELQLK ERGQHGHTGS SLHVALLSGV LVTDVCWEVL FFTLQTTGNL
KELDLSGNCL SNTTVWSLCE ALRFPCCHLE TLRLVGCGLT SSCCRALASV LSTSPSLTEL
DLQQNELEDA GVRLLCEGLR HPTCQLRLLW LDQTRLSEEV TRMLRALEDE KPRLLIRSRR
KPSETMPNEG PSETMPNEGP REGETSGTSS LQQDRRESEG LSPQVAQEGL ASLPSPAPPE
NLHTGPLGTE DDFWGPLGPV AIEVVDKDRS LHRVHLPMAG SYRWPSTGLR FVVREPATID
IEFCASDKFL HEMAWEQSWM VAGPLFDIKV KPRAVATMYL PHFVDLRGGC VDTSLFQVAH
FKEPGMLLEK PTRVELYHVV LEDPSFSPIG VFLRTIHAAL RFLPVTSMVL LYHHTRLDET
VFHLYLIPSD CCVRKAIDDE EKAFQFVQIR KPPPLASLYL GSRYAVSSSE TLEAIPKELE
LCYRSPGQPQ LYSEFYVGDL GSGLRLQLKE ESGAVVWEAL VKPGDLQLAS SLVPPAPAAS
PAPPGAPASL HFLDRHREQL VARVTTVDPV LDKLLGQVLS EEQYDQVRAK ATAANQMREL
FRFNRSWDLA CKDQVYQALK ETHPYLIMEL WETWGGDRER GASPLAQ
//
