ID A0A2Y9L4L0_ENHLU Unreviewed; 513 AA.
AC A0A2Y9L4L0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Leucine-rich repeat LGI family member 4 isoform X3 {ECO:0000313|RefSeq:XP_022380841.1};
GN Name=LOC111161464 {ECO:0000313|RefSeq:XP_022380841.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022380841.1};
RN [1] {ECO:0000313|RefSeq:XP_022380841.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022380841.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_022380841.1; XM_022525133.1.
DR AlphaFoldDB; A0A2Y9L4L0; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR009039; EAR.
DR InterPro; IPR005492; EPTP.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24367:SF268; LEUCINE-RICH REPEAT LGI FAMILY MEMBER 4; 1.
DR PANTHER; PTHR24367; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF03736; EPTP; 4.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50912; EAR; 6.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..513
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016047082"
FT DOMAIN 134..183
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REPEAT 186..228
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 232..274
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 327..370
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 372..415
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 417..459
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
FT REPEAT 463..508
FT /note="EAR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00075"
SQ SEQUENCE 513 AA; 56545 MW; 5BBA73273C637943 CRC64;
MGGAGVLLLL LAGAGVGVAW RPPKGKCPLS CSCSKDSALC EGSPDLPENF SPTLLSLLFT
SNSFSVIEDD AFAGLSHLQY LFIEDNEIGS ISKNALRGLR SLTHLSLANN NLETLPRYLF
RGLETLTHVD LRGNPFQCDC RVLWLLQWTP TVNASVGTGA CAGPPALAHM QLRHLDPKTF
KCRAIELSWF QTVGESALGV ESFSYQGEPH IVLAQPFAGR CLILTWDYSL QRFRPEEELS
APSVVSCKPL VLGLRLFVLA ARLWGGSQLW ARPSPGLRLA PTQALAPRRL LRPNDAELLW
LDGQPCFVVA DASKAGSTTL LCQDGPGFYP RQSLHAWHRD TDAEALELDG RPHLLLASAS
QRPVLFQWLS GRFERRTDIP EAEDVYATRH FQAGGDVFLC LTRYIGDSMV MRWDGSMFRL
LQQLPSRGAH VFQPLLIARD QLAILGSDFA FSQVFRLEPD KGLLEPLQEL GPPALVAPRA
FAHITIAGRR FLFAACFKGP TQIYQHHELD LSA
//
