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Database: UniProt
Entry: A0A2Y9L592_ENHLU
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ID   A0A2Y9L592_ENHLU        Unreviewed;       597 AA.
AC   A0A2Y9L592;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Estrogen receptor {ECO:0000256|ARBA:ARBA00015934, ECO:0000256|PIRNR:PIRNR002527};
DE            Short=ER {ECO:0000256|PIRNR:PIRNR002527};
DE   AltName: Full=ER-alpha {ECO:0000256|ARBA:ARBA00031973, ECO:0000256|PIRNR:PIRNR002527};
DE   AltName: Full=Estradiol receptor {ECO:0000256|ARBA:ARBA00031699, ECO:0000256|PIRNR:PIRNR002527};
DE   AltName: Full=Nuclear receptor subfamily 3 group A member 1 {ECO:0000256|ARBA:ARBA00032418, ECO:0000256|PIRNR:PIRNR002527};
GN   Name=LOC111158708 {ECO:0000313|RefSeq:XP_022376630.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022376630.1};
RN   [1] {ECO:0000313|RefSeq:XP_022376630.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022376630.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC       regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC       {ECO:0000256|PIRNR:PIRNR002527}.
CC   -!- SUBUNIT: Binds DNA as a homodimer. {ECO:0000256|PIRNR:PIRNR002527}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
CC       Nucleus {ECO:0000256|PIRNR:PIRNR002527}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000256|ARBA:ARBA00005413,
CC       ECO:0000256|PIRNR:PIRNR002527}.
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DR   RefSeq; XP_022376630.1; XM_022520922.1.
DR   AlphaFoldDB; A0A2Y9L592; -.
DR   KEGG; elk:111158708; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030284; F:nuclear estrogen receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd07171; NR_DBD_ER; 1.
DR   CDD; cd06949; NR_LBD_ER; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR024178; Est_rcpt/est-rel_rcp.
DR   InterPro; IPR001292; Estr_rcpt.
DR   InterPro; IPR046944; Estr_rcpt_N.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR024736; Oestrogen-typ_rcpt_final_C_dom.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092:SF16; ESTROGEN RECEPTOR; 1.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   Pfam; PF12743; ESR1_C; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF02159; Oest_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PIRSF; PIRSF500101; ER-a; 1.
DR   PIRSF; PIRSF002527; ER-like_NR; 1.
DR   PRINTS; PR00543; OESTROGENR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR002527};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121,
KW   ECO:0000256|PIRNR:PIRNR002527};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002527};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR002527};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Steroid-binding {ECO:0000256|ARBA:ARBA00022665,
KW   ECO:0000256|PIRNR:PIRNR002527};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR002527};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR002527}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          182..257
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          311..547
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          143..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  66270 MW;  7BD189BB047598C3 CRC64;
     MTMTLHTKAS GMALLHQIQG TELEPLNRPQ LKIPLERPLG EVYVDSSKPA VYNYPEGGAY
     DFNAAPAASA PVYGQSGLSY GPGSEAAAFG ANGLGGFQPL NSVSPSPLVL LHPPPQLSPF
     LHPHGQQVPY YLENEPSGYA VREAGPPAFY RPNSDSRRQG GRERLASTSD KGSMAMESAK
     ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC
     RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDAEGRNEV GSSGDMRTSN LWPSPLLIKH
     TKKNSPALSL TADQMVSALL EAEPPIIYSD YDPSRPFSEA SMMGLLTNLA DRELVHMINW
     AKRVPGFVDL SLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG
     MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD
     KITDTLIHLM AKAGLTLQQQ HRRLAQLLLI LSHIRHMSNK GMEHLYSMKC KNVVPLYDLL
     LEMLDAHRLH APAGRGGGSA PMEEMSESQL ATTGATSSHS LQAYYITEEP GSFPTTV
//
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