ID A0A2Y9L5U7_ENHLU Unreviewed; 225 AA.
AC A0A2Y9L5U7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=MIF4G domain-containing protein isoform X1 {ECO:0000313|RefSeq:XP_022378983.1, ECO:0000313|RefSeq:XP_022378984.1};
GN Name=LOC111160303 {ECO:0000313|RefSeq:XP_022378983.1,
GN ECO:0000313|RefSeq:XP_022378984.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022378984.1};
RN [1] {ECO:0000313|RefSeq:XP_022378983.1, ECO:0000313|RefSeq:XP_022378984.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022378983.1,
RC ECO:0000313|RefSeq:XP_022378984.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in replication-dependent translation of histone
CC mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC with a poly-A tail but a stem-loop. May participate in circularizing
CC those mRNAs specifically enhancing their translation.
CC {ECO:0000256|ARBA:ARBA00037643}.
CC -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC interacts with eif4g1 which is bound to their 5'-end.
CC {ECO:0000256|ARBA:ARBA00038641}.
CC -!- SIMILARITY: Belongs to the MIF4GD family.
CC {ECO:0000256|ARBA:ARBA00038204}.
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DR RefSeq; XP_022378983.1; XM_022523275.1.
DR RefSeq; XP_022378984.1; XM_022523276.1.
DR STRING; 391180.A0A2Y9L5U7; -.
DR KEGG; elk:111160303; -.
DR OrthoDB; 4208729at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23254; EIF4G DOMAIN PROTEIN; 1.
DR PANTHER; PTHR23254:SF17; MIF4G DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 8..205
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
SQ SEQUENCE 225 AA; 25682 MW; 10F9E452E0CC989A CRC64;
MGDPGREEYK IQSFDAETQH LLKTALKDPG AVDLEKVANV IVDHSLHDCV FSKEAGRMCY
AIIQAESKHA GQSVFRRGLL NRLQQEYQAR EQLRARSLQG WVCYVTFICN VFDYLRVNNM
PMMALVNPVY DCLFRLAQPD SLSKEEEVDC LVLQLHRVGE QLEKMNRQRM DELFVLIRDG
FLLPSGLSSL AQLLLLEIIE FRAAGWKTTP AAHKALVVKS LQQLM
//
