ID   A0A2Y9L6Y5_ENHLU        Unreviewed;      1070 AA.
AC   A0A2Y9L6Y5;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=ADAMTS-like protein 4 isoform X2 {ECO:0000313|RefSeq:XP_022381756.1};
GN   Name=LOC111161954 {ECO:0000313|RefSeq:XP_022381756.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022381756.1};
RN   [1] {ECO:0000313|RefSeq:XP_022381756.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022381756.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022381756.1; XM_022526048.1.
DR   AlphaFoldDB; A0A2Y9L6Y5; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 6.
DR   Pfam; PF00090; TSP_1; 1.
DR   SMART; SM00209; TSP1; 7.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 6.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..1070
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015883121"
FT   DOMAIN          1025..1062
FT                   /note="PLAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50900"
FT   REGION          77..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..95
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1070 AA;  116870 MW;  BE80276DCC4FD56A CRC64;
     MEKWAGRPQL CLMLLLSLPE LGLDQEVLSG HSLQTPPEEG QGPEGVWGPW EQWASCSQPC
     GVGVQRRSRT CQLPTARLHQ GLPFPPRPPR HPEALLPRGQ SPRPQTSRET LPLYRPQPRG
     RGGPRRGPAS QLGRAETREI TGARGSRVRD PIKPGMFGYG RVPFALPLHR NRRHPRRLPG
     AETSQTSDLP SLTPRTEPFS TNHTVQTQFP PIELSARPPH PPAELPSPET NQTEVPSRTR
     PVPTQPHPRV QASGTEPASS IPYPGESNSF HVSPQPRMPD SQGSASLQVA ERYPNPFLSV
     LRGRGHQSQE HWKPGGNLHG SLMEPAPHYP DGWLPLLNDG PHSGSLWSLF APDRPVPRCS
     GEREQLRACS QAPCPPEQPD PRALQCAAFD SQEFMGQLYQ WEPFTEVQGS QRCELNCRPR
     GFRFYVRHTE KVQDGTLCQP GALDICVAGR CLSPGCDGIL GSGRRPDGCG VCGGDDSTCH
     LVSGNLTDRG GPLGYQKILS IPVGATQLQI AQLRPSSNYL ALRGPGGQSI INGNWAVDPP
     GSYTASGTVF LYNRPSREEG KGESLSAKGP TTQPVDVYVI FQEENPGIFY QYIISSVLPD
     LGSTTPEPHF PQLQPEILRV EPPPASMPRP ARTPGTLQRQ VRIPQMHAPP HPRTPLGSPA
     GYWKRVGHSE CSASCGKGVW RPVFLCVSRE SGEELDEHSC AMGVRPPAPL EPCHGPPCPP
     YWEAGEWTSC SRSCGSGTQH RQLRCRQEFG GGGSSVPPER CGHLPRPNAT QPCQLRLCGH
     WEVRSPWSQC SVRCGRGQRS RQVRCVGSNG DEVSERECAS GPPQPPSREA CDMGPCTTAW
     FHSDWSSKCS AECGTGIQRR SVVCLGSGES RGAGQEEAGA GTTEQSCALG SRPPDMRACS
     LGPCEMTWCW YTGPWAECSS ECGSGTQRRD IICVSKLGTE FNVTSPSNCS HLPRPPALQP
     CQGQDCQDRW FSTPWSPCSR SCQGGIQTRE VQCLTANQTL SVRCPPHLRP SRKRPCNSQP
     CSQRPDDQCK DSSPHCPLVV QARLCVYPYY TATCCRSCAH VLERSPPEPA
//