ID A0A2Y9L744_ENHLU Unreviewed; 721 AA.
AC A0A2Y9L744;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Tripartite motif-containing protein 67 isoform X2 {ECO:0000313|RefSeq:XP_022379414.1};
GN Name=LOC111160536 {ECO:0000313|RefSeq:XP_022379414.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379414.1};
RN [1] {ECO:0000313|RefSeq:XP_022379414.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379414.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_022379414.1; XM_022523706.1.
DR AlphaFoldDB; A0A2Y9L744; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19844; Bbox1_TRIM67_C-I; 1.
DR CDD; cd19827; Bbox2_TRIM67_C-I; 1.
DR CDD; cd00063; FN3; 1.
DR CDD; cd12889; SPRY_PRY_TRIM67_9; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF21; TRIPARTITE MOTIF-CONTAINING PROTEIN 67; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 172..215
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 236..278
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 386..444
FT /note="COS"
FT /evidence="ECO:0000259|PROSITE:PS51262"
FT DOMAIN 450..545
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 527..712
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 721 AA; 78138 MW; 248F46800EC9978B CRC64;
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GDGSAAGGLG GGAGGGGDHA
DKLSLYSETD SGYGSYTPSL KSPNGVRVLP MVPAPPGSSA AAARGAACSS LSSSSSSSIT
CPQCHRSASL DHRGLRGFQR NRLLEAIVQR YQQGRGAVHG ASAAAAVAIC QLCDRTPPEP
AATLCEQCDV LYCAACQLKC HPSRGPFAKH RLGAPSGGGG CKSPGGAGAA GGSAARKFPT
CPEHEMENYS MYCVSCRTPV CYLCLEEGRH GKHEVKPLGA MWKQHKAQLS QALNGVSDKA
KEAKEFLVQL KNILQQIQEN GLDYEACLVA QCDALVDALT RQKAKLLTKV TKEREHKLKM
VWDQINHCTL KLRQSTGLME YCLEVIKEND PSGFLQISDA LIKRVQVSQE QWVKGALEPK
VSAEFDLTLD SEPLLQAIHQ LDFIQMKCRV PLSPLLQLEK CCTHNNSVTL AWRMPPFTHS
PVDGYILELD DGDGGQFREV YVGKETLCTI DGLHFNSTYN ARVKAFNSSG VGPYSKTVVL
QTSDVAWFTF DPNSGHRDII LSNDNQTATC SSYDDRVVLG TAAFSKGVHY WELHVDRYDN
HPDPAFGVAR ASVVKDMMLG KDDKAWAMYV DNNRSWFMHC NSHTNRTEGG VCKGATVGVL
LDLNKHTLTF FINGQQQGPT AFSHVEGVFM PALSLNRNVQ VTLHTGLEVP TNLGRPRLSG
N
//
