ID A0A2Y9L7Q0_ENHLU Unreviewed; 357 AA.
AC A0A2Y9L7Q0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Septin-1 {ECO:0000313|RefSeq:XP_022382212.1};
GN Name=LOC111162235 {ECO:0000313|RefSeq:XP_022382212.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022382212.1};
RN [1] {ECO:0000313|RefSeq:XP_022382212.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022382212.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
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DR RefSeq; XP_022382212.1; XM_022526504.1.
DR AlphaFoldDB; A0A2Y9L7Q0; -.
DR STRING; 391180.A0A2Y9L7Q0; -.
DR KEGG; elk:111162235; -.
DR OrthoDB; 5396944at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF6; SEPTIN-1; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR006698-
KW 2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR006698-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 22..296
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT COILED 316..350
FT /evidence="ECO:0000256|SAM:Coils"
FT SITE 144
FT /note="Important for dimerization"
FT /evidence="ECO:0000256|PIRSR:PIRSR006698-2"
SQ SEQUENCE 357 AA; 41016 MW; 77222E8A076B1ABE CRC64;
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL YEDRQLPEAS
ARLTQTLTIE RRGVEIEEGG IKVKLTVVDT PGFGDSVDCS DCWQPVVRYI EEQFEQYLRD
ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP LDVAFLRAVH EKVNIIPVIG KADALMPKET
QALKQKIRNQ LKEEEINIYQ FPDCDSDEDE DFKRQDAEMK ESIPFAVVGS CEVVRNGGTR
PVRGRRYSWG TVEVENPHHC DFLNLRRMLV QTHMQDLKEV THDLLYEGYR ARCLQSLARK
LSRQSATEIP LPMLPLADTE KLIREKDEEL RRMQEMLEKM QAQMQQSQTQ GEQSDAL
//
