ID A0A2Y9L8P3_ENHLU Unreviewed; 1324 AA.
AC A0A2Y9L8P3;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Son of sevenless homolog 2 isoform X2 {ECO:0000313|RefSeq:XP_022379999.1};
GN Name=LOC111160889 {ECO:0000313|RefSeq:XP_022379999.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379999.1};
RN [1] {ECO:0000313|RefSeq:XP_022379999.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379999.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022379999.1; XM_022524291.1.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 190..380
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 433..536
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 587..731
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 770..1009
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1010..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1165..1181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1293
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1324 AA; 152093 MW; D1EFA5EAE14B6FB7 CRC64;
MQQAPQPYEF FSEENSPKWR GLLVSALRKV QEQVHPTLSA NEESLYYIEE LIFQLLNKLC
MAQPRTVQDV EERVQKTFPH PIDKWAIADA QSAIEKRKRR NPLLLPVDKI HPSLKEVLGY
KVDYQVSLYI VAVLEYISAD ILKLAGNYVF NIRHYEISQQ DIKVSMCADK DDIGLVSLCE
DEPSSSGELN YYDLVRTEIA EERQYLRELN MIIKVFREAF LSDRKLFKPS DIDRIFSNIS
DIHELTVKLL GLIEDTVEMT DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPKFNEH
FSKLMARPAV ALHFQSIADG FKEAVRYVLP RLMLVPVYHC WHYFELLKQL KACSEDQEDR
ECLNQAITAL MNLQGSMDRI YKQYSPRRRP GDPVCPFYNR QLRSKHLAIK KMNEIQKNID
GWEGKDIGQC CNEFIMEGPL TRIGAKHERH IFLFDGLMIS CKPNHSQSRL PGYSSAEYRL
KEKFVMRKIQ ICDKDDTCEY KNAFELVSKE ENSIIFAAKS AEEKNNWMAA LISLHYRSTL
DRMLDSVLLK EENEQPLRLP SPDVYRFVVK DSEENIVFED NLQSRSGIPI IKGGTVVKLI
ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLLIERFEI PEPEPTEADK LAIEKGEQPV
SADLKRFRKE YVQPVQLRIL NVFRHWVEHH FYDFERDLEL LERLESFISS VRGKAMKKWV
ESIAKIIKRK KQAQANGISH NITFESPPPP IEWHISRPGQ FETFDLMTLH PIEIARQLTL
LESDLYRKVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV EAENFEERVA
ILSRIIEILQ VFQDLNNFNG VLEIVSAVNS VSVYRLDHTF EALQERKRRI LDDAVELSQD
HFKKYLVKLK SINPPCVPFF GIYLTNILKT EEGNNDFLKK KGKDLINFSK RRKVAEITGE
IQQYQNQPYC LRIEPEMRRF FENLNPMGSA SEKEFTDYLF NKSLEIEPRN CKQPPRFPRK
STFSLKSPGI RPNTGRHGST SGTLRGHPTP LEREPCKMSF SRIAETDLES TVSAPTSPNT
PSTPPVSASS DLSVFLDVDL NSSCGSNSIF APVLLPHSKS FFSSCGSLHK LSEEPLIPPP
LPPRKKFDHD ASNSKGNMKS DDDPPAIPPR QPPPPKVKPR VPAPAGTFDG PLHSPPPPPP
RDPLPDTPPP VPLRPPEHFI NCPFNLQPPP LGHLHRDPDW FRDVSTCPNS PNTPPSTPSP
RVPRRCYVLS SSHNNLAHPQ APPVPPRQNS SPHLPKLPPK TYKRELSHPP SYRLPLLENA
ETPQ
//
