ID A0A2Y9L900_ENHLU Unreviewed; 1008 AA.
AC A0A2Y9L900;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=LOC111162426 {ECO:0000313|RefSeq:XP_022382541.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022382541.1};
RN [1] {ECO:0000313|RefSeq:XP_022382541.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022382541.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR RefSeq; XP_022382541.1; XM_022526833.1.
DR AlphaFoldDB; A0A2Y9L900; -.
DR STRING; 391180.A0A2Y9L900; -.
DR KEGG; elk:111162426; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT DOMAIN 389..468
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 113011 MW; 1BD439206BF05C58 CRC64;
MGADARPSGV RAGGGGRAVA GPKTGSRALQ PPLPPLSFLF LLLVAAPGAR AAGYETCPVV
HPDMLNVHLV AHTHDDVGWL KTVDQYFYGI QNDVQHAGVQ YILDSVISSL LVEPTRRFIY
VEIAFFSRWW HQQTNATQEV VRELVRQGRL EFANGGWVMN DEAATHYGAI IDQMTLGLRF
LENTFGKDGR PRVAWHIDPF GHSREQASLF AQMGFDGFFF GRLDYQDKSM RKEKQEMEQV
WRASASLKPP VADLFTSVLP NMYNPPEKLC WDTLCADKPF VEDPRSPEYN AKELVDYFLQ
LATAQGQYYR TNHTIMTMGS DFQYENANMW FKNLDRLIQL VNAQQQANGS RVNVLYSTPA
CYLWELNKAN LTWSVKQDDF FPYADGPYKF WTGYFSSRPA LKRYERLSYN FLQVCNQLEA
LAGPVANVGP YGSGDSAPLN EAMAVLQHHD AVSGTSRQHV ANDYARQLAA GWGPCEILLS
NALARLSGSK EDFTYCRNLN VSVCPLSQTA KSFQVIIYNP LGRKVDWMVR LPVSEHFFDV
RDPNGTVVPS DVVIHPSSDN SELLFSASVP ALGFSVYSVT QVPGRNLHAH NRHLRSQKSW
SHDLAIQNEH LRAKFDPDTG LLVELENLDQ NLLLPVRQAF YWYNASVGNS LSSQASGAYI
FRPDRQKPLI VSHWAQTRVV KTPLVQEVHQ NFSAWCSQVV RLYPGQRHLE LEWTVGPIPV
GDGWGKEVIS RFDTVLETKG LFYTDSNGRE ILERRRDYRP TWKLNQTEPV AGNYYPVNSR
IYIRDGKTQL TVLTDRSQGG SSLKDGSVEL MVHRRLLKDD GRGVGEPLLE DGLGLWVRGR
HLVLLDKVSA AATRHRLQAE KELLAPQVVL APGGGAPYHP EVAPLKQFSG LRRELPPSVH
LLTLARWDRT SLLLRLEHQF AVGEGSGNLS APVTVDLKDL FSAFTITDLQ ETTLAANQLR
AGASRLKWTP ATGPAPQPSP PRLDPAAITL QPMEIRTFLA LVQWKELG
//