ID A0A2Y9L9I1_ENHLU Unreviewed; 790 AA.
AC A0A2Y9L9I1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Pleckstrin homology domain-containing family G member 6 {ECO:0000313|RefSeq:XP_022378130.1};
GN Name=LOC111159805 {ECO:0000313|RefSeq:XP_022378130.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022378130.1};
RN [1] {ECO:0000313|RefSeq:XP_022378130.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022378130.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022378130.1; XM_022522422.1.
DR AlphaFoldDB; A0A2Y9L9I1; -.
DR STRING; 391180.A0A2Y9L9I1; -.
DR KEGG; elk:111159805; -.
DR OrthoDB; 2881273at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042918; PLEKHG6.
DR PANTHER; PTHR47671; PLECKSTRIN DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR PANTHER; PTHR47671:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 161..353
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 409..509
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 30..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 88871 MW; 35F125950728943D CRC64;
MQTFVPPDEG PFQGLVASRI ETYRGHYQAS NQGSADHLHS QVAPGLDPGR QHLHGYVPFA
KGSGQVRGVS PLKMREPEPE KKYGGPFGSG PPHSPKFKEV SKARQLEMRL HTFSIFGMPR
LPPEERRHWE IGEGSDSSLV IEKSWKELVP GHKEMSRELC HQQEALWELL TTELIYVRKL
KIMTNLLTAG LLNLQRVGLL TEVSAETLFG NVPSLIRAHK SFWEEVLGPT LGETRASGQP
LDPVSLQNGF LTFSQRFQPY VQYCLQVKRT MAYAREQQDN NPLFHAFVQW CEKHKLAGRQ
MLGDLLIKPH QRVTKYPLLL QAVLKRSPEA HVQEALSAMI ASVESFLRHI NQLVHRSEEQ
ESLVAAARRI GPYDVLEPSS EEVQKNLRPF CTLDLTSPML GVASEYIRQL LLEGPARVKE
GREGKLDVYL FLFSDVLLVT KPQRKVNKAK VIRPPLMLEK LVCRPLRDPN SFLVIHLTEF
HCVSSALTVQ CPSATDRAQW LEKTQQAQVT LQKLKAEEYV QQKRELLALY RDQDQESPGT
RPSSPSLEGS QSSAEGRTPE FSTIIPHPVV TEDTDEDSLL VPDDTSDSGY GTLIPGSPKG
PYHLSRLRPQ ALRRDPRLTF STLDLRDVPL RPQPPNFQAP QHRSAPELPR EVIQRGSSLP
RGDPPTWSEE EDGTLVGGNV VAETLHRAQL RGKLPPSPTH TDSAGESPWE SSGDEEEESL
FLGTRCTPHS RTLRAEDMLR EIREDLASQR IEAIPELGNS RPWKLTRGQL QRMRGSCIVQ
LDTPMSVSEV
//
