ID A0A2Y9LA45_DELLE Unreviewed; 2472 AA.
AC A0A2Y9LA45;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Tetratricopeptide repeat protein 28 isoform X2 {ECO:0000313|RefSeq:XP_022406550.1};
GN Name=TTC28 {ECO:0000313|RefSeq:XP_022406550.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022406550.1};
RN [1] {ECO:0000313|RefSeq:XP_022406550.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022406550.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022406550.1; XM_022550842.2.
DR Proteomes; UP000248483; Unplaced.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR024983; CHAT_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10098; RAPSYN-RELATED; 1.
DR PANTHER; PTHR10098:SF106; TETRATRICOPEPTIDE REPEAT PROTEIN 28; 1.
DR Pfam; PF12770; CHAT; 1.
DR Pfam; PF13424; TPR_12; 10.
DR Pfam; PF13176; TPR_7; 2.
DR SMART; SM00028; TPR; 25.
DR SUPFAM; SSF48452; TPR-like; 7.
DR PROSITE; PS50005; TPR; 11.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 126..159
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 314..347
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 354..387
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 394..427
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 514..547
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 594..627
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 634..667
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 877..910
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 957..990
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 997..1030
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 1077..1110
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1391..1713
FT /note="CHAT"
FT /evidence="ECO:0000259|Pfam:PF12770"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1997..2049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2066..2330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2413..2444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 970..997
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2020..2038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2083..2140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2176..2220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2286..2325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2472 AA; 269821 MW; 721975AAC9248BFC CRC64;
MEQSPPPALE PTPGSTPARS RRRREPESPP APPPIPLFGA KTIGRRSPDG PVLSKAEFVE
KVRQSNQACH DGDFHTAIVL YNEALAVDPQ NCILYSNRSA AYMKIQQYDK ALDDAIKARL
LNPKWPKAYF RQGVALQYLG RHADALAAFA SGLAQDPKSL QLLVGMVEAA MKSPMRDSLE
PTYQQLQKMK LDKSPFVVVS VVGQELLTAG HHGASVVVLE AALKIGTCSL KLRGSVFSAL
SSAYWSLGNT EKSTGYMQQD LDVAKTLGDQ TGECRAHGNL GSAFFSKGNY REALTNHRHQ
LVLAMKLKDR EAASSALSSL GHVYTAIGDY PNALASHKQC VLLAKQSKDE LSEARELGNM
GAVYIAMGDF ENAVQCHEQH LKIAKDLGNK REEARAYSNL GSAYHYRRNF DKAMSYHNYV
LELAQELMEK AIEMRAYAGL GHAARCMQDL ERAKQYHEQQ LGIAEDLKDR AAEGRASSNL
GIIHQMKGDY DTALKLHKTH LCIAQELSDY AAQGRAYGNM GNAYNALGMY DQAVKYHRQE
LQISMEVNDR ASQASTHGNL AVAYQALGAH DRALQHYQNH LNIARELRDI QSEARALSNL
GNFHCSRGEY VQAAPYYEQY LRLAPELQDM EGEGKVCHNL GYAHYCLGNY QEAVKYYEQD
LALAKDLHDK LSQAKAYCNL GLAFKALLNF NKAEECQKYL LSLAQSLNNS QAKFRALGNL
GDIFICKKDI SGAIKFYEQQ LGLAHHVKDR RLEASAYAAL GTAYRMIQKH DKALGYHTQE
LEVYQELSDL PGECRAHGHL AAVYMALGKY TMAFKCYEEQ LDLGQKLKDP SLEAQVYGNM
GITKMNMNVM EEAIGYFEQQ LAMLQQLSGN ESVLDRGRAY GNLGDCYEAL GDYEEAIKHY
EQYLSVAQSL NRMQDQAKAY RGLGNGHRAM GSLQQALVCF EKRLVVAHEL GEAFNKAQAY
GELGSLHSQL GNYEQAISCL ERQLNIAREM KDRALESDAA CGLGGVYQQM GEYDTALQYH
QLDLQIAEET NNPTCQGRAY GNLGLTYESL GTFERAVVYQ EQHLSIAAQM NDLVAKTVSY
SSLGRTHHAL QNYSQAVMYL QEGLRLAEQL GRREDEAKIR HGLGLSLWAS GNLEEAQHQL
YRASALFETI RHEVQLSTDY KLSLFDLQTS SYQALQRVLV SLGHHDEALA VAERGRTRAF
ADLLVERQTG QQDSDPYSPV TIDQILEMVN GQRGLVLYYS LAAGYLYSWL LAPGAGILKF
HEHYLGDNTV ENSSDFQAGS STALPTATSS ALEQHIASVR EALGVESYYS RACASSETES
EAGDIMDQQF EEMNNRLNSV TDPTGFLRMV RRNNLFNRSC QSMTSLVGNA TSPIKDGTSS
LPRRQSSFAR PPLRALYDLL VAPMEGGLMH SSGPVGRHRQ LVLVLEGELY LIPFALLKGS
SSNEYLYERF ALIAVPSIRS LGPQAKSHLR KNPPAYCSST SMAAVVGNPK LPSAVMDRWL
WGPMPSAEEE AYMVSELLGC QPLVGSMATK ERVMSALTQA ECVHFATHIS WKLSALVLTP
SVEGTPAGSK SSFGHPYTIP ESLRVQDDTS DGESISDCPP LQELLLTAAD VLDLRLPVKL
VVLGSSQESN SKVTADGVIA LTRAFLAAGA QCVLVSLWPV PVAASKMFLH ALYSSLLNGL
KASAALGEAM KVVQSSKAFS HPSNWAGFLL IGSDVKLNSP SSLIGQALTE ILQHPERARD
ALRVLLHLVE KSLQRIQNGQ RNAMYTSQQS VENKVGGIPG WQALLTAVGF RLDPPASGLP
AAVFFPTSDP GDRLQQCSST IQSLLGLPNP ALQALCKLIT ASETGEQLIS RLHQVLVQLQ
AGEKEQDFAS APIQVSISVQ LWRLPGCHEF LAALGFDLCE VGQEEVILKT GKQANRRTMH
FALQALLALF DSTELPKRLS LDSSSSLESL ASAQSVSNAL PLGYQHPPFS PTGAESIASD
AISVYSLSSI ASSMSFVSKP EGGSEGGGPR GRQDYDRSKN AFPQRSTLPR SQLSPPTRPA
DSKDEEEYEG FSIISTEPLA AYQENRQTRF SPDHKQSRVG TAGGVKVSVS SKGSISTPNS
PVKMTLIPSP NSPFQKVGKL ASSDTGESDQ SSTETDSTVK SQEESNPKLD PQELAQKILE
ETQSHLIAVE RLQRGSGQGK GTNPEDGISV PNSAAVFRAS ETSAFSRPAL SHQKSQLSPV
TIKPKPPARS SSLPKVSSGY SSPTASEASI KDSPSQHSGR PSPGSDSQTS LTDQPLFKLK
YPSSPYSAHI SKSPRNMSPS SGHQSPAGSA PSPALSYSSA GSARSSPADA PDIDKLKMAA
IDEKVQAVHN LKMFWQSTPQ HSTGPMKIFR GTPGTMTSKR DVLSLLNLSP RHSKKEEGAD
KLELKELSLQ QCGETPPKAP PNGHWHTETT SLSTLPLPAG PPAAVPTRPL RLPSGNGYKF
LSPGRFFPSS KC
//
