ID   A0A2Y9LBY2_ENHLU        Unreviewed;       723 AA.
AC   A0A2Y9LBY2;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 3 isoform X1 {ECO:0000313|RefSeq:XP_022382728.1};
GN   Name=LOC111162533 {ECO:0000313|RefSeq:XP_022382728.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022382728.1};
RN   [1] {ECO:0000313|RefSeq:XP_022382728.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022382728.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_022382728.1; XM_022527020.1.
DR   AlphaFoldDB; A0A2Y9LBY2; -.
DR   STRING; 391180.A0A2Y9LBY2; -.
DR   KEGG; elk:111162533; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17212; RA_RGL3; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030750; RGL3_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT   DOMAIN          65..200
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          247..505
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          626..713
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          504..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..553
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..591
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  78858 MW;  3F3DC3DD198E3276 CRC64;
     MDRTAGKELV LAPLQDWGEE TEDGAVYSVS LRRQLSQRLS PRAGPGGSQA SNPTADAFLH
     YRTSKVRALR AARLERLVQE LVSGDREQDP GFVPAFLATH RAFVSTARVL GLLLPPPPPP
     LPPGIEIKKT EGGGLRVNKN LRAVVSVLGS WLRDHPQDFR DPPAHSDLGS VCTFLGWAAP
     AGPEAQEAEK LLGDFLEEAE QKQEEKKPEA WTGPPGAVHT PCPDFPDDCS EEEAGPVREG
     PELLDFSVDE LAEQLTLLDV ELFSRVRSCE CLGSVWSQRD RPGAASTAPT VRATVTQFNM
     VIGCVLGSVL GEQGLAAPQR AQRLEKWIRV AQRCRELRNF SSLRAILSAL QSNPIYRLKR
     SWGAVSRERL STFRKLSQIF SDENNHLSSR EILSQEEATE GPQEEDTFPG NLPPKLPPGP
     VPYLGTFLTD LVMLDTALPD MLEGDLINFE KRRKEWEILA HIQQLQKRCG SYCLSPRTPV
     LAALRAQCQL SEEQSYRVSR VIEPPAASCP SSPHVRRRIS PTKRLSAKLS RERRSSPAGS
     PGDPSSPTSS SGQPLDLGLC VSCSLSPGSP PSSPRTRDPP GSPPASPGPQ GPNTKLPLSL
     DLPALRLLAL PLSSSHISVP GQPGSEARVI RVSIDNDHGN LYRSILLTSQ DKAPSVVQRA
     LEKHNVAQPW ARDYQLFQVL PGDRELLIPD NANVFYAMSP AAPGDFVLRR KEGARPTTTI
     SSA
//