ID A0A2Y9LD73_ENHLU Unreviewed; 1207 AA.
AC A0A2Y9LD73;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 4 isoform X1 {ECO:0000313|RefSeq:XP_022379455.1};
GN Name=LOC111160558 {ECO:0000313|RefSeq:XP_022379455.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022379455.1};
RN [1] {ECO:0000313|RefSeq:XP_022379455.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022379455.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_022379455.1; XM_022523747.1.
DR AlphaFoldDB; A0A2Y9LD73; -.
DR STRING; 391180.A0A2Y9LD73; -.
DR KEGG; elk:111160558; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF6; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF140860; Pseudo ankyrin repeat-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_022379455.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 689..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 924..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..324
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 783..1046
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1188..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1127..1178
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1192..1207
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 134155 MW; DF9596534C303026 CRC64;
MVGPEKEQSW IPKIFKKKTC TTFIVDPTDA GGDLCQCGRP RSAHPSVAME DAFGAAVVTV
WDSDLHTTEK PTDAYGDLDF LGAGRKASNF LRLSDRTDPA TVYNLVTRTW GFPAPNLVVS
VLGGSGGPTL HTWLQDLLRR GLVRAAQSTG AWIVTGGLHR GIGRHVGVAV RDHQTASTGG
TKVVAMGVAP WGVVRNRDAL TNPKGSFPAT YPWRGDREDG VQFPLDYNYS AFFLVDDGTH
GRLGGENRFR LRFESYIAQQ KTGVGGTGID IPVLLLLIDG DEKMLKRIEN ATQAQLPCLL
VAGSGGAADC LAEILEDTVA PGRGESKRGE AWDRIKRFFP RGDPEVLQAQ VERIMTRKEL
LTVYSSEDGP EEFETIVLKA LVKACGSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIEW
RSVHLEASLM DALLNDRPEF VRLLISHGLS VGHFLTPARL TQLYSAAPPN SLIRSLLDQA
SHGTGTKSPV FKSPAEPRPP DVGQVLRMLL GETRAPRYSA GGAGDPHQGQ GCRESVGLLS
DRAPSELMLD AILGQAPWSD LLLWALLLNR AQMAVYFWEM GSNAVASALG ACLLLRVLAR
LESEAEEAAR RKDLAAKFEG LGVDLFGECY RSSEKRAARL LLRRCPLWGD ATCLQLAMQA
DARAFFAQDG VQSLLTQKWW GEMDSTTPIW ALVLAFFCPP LIYTNLITFR KSEDESVQKD
LAFDIDRGLN GEGPVGLAEP REKKAMRVLG QPRRRGCPPR LRRWPQFWGA PVTAFMGNVV
SYLLFLLLFA WVLIVDFQPG APSALELLLY FWAFTLLCEE FRQGLGGGWG SLATRGPGPG
PQQAPLRRRL SFYLADTWNQ CDLVALTCFL LGVGCRLTPG LYDLGRTVLC LDFMVFTLRL
LHIFTVNKQL GPKIVIVNKM MKDVFFFLFF LGVWLVAYGV ATEGLLRPRD RDLPNVLRRV
FYRPYLQIFG QIPQEDMDVA LMEHANCSSE HGFWARPPGA QAGSCVSLYA NWLVVLLLII
FLLVANILLL NLLIAMFSDT FGKVQGNSDL YWKAQRYSLI REFHSRPALA PPLIIISHVR
LLIRQLRRRR SRLPPSPVVE HFRVCLSKEA ERRLLTWESV QKENFLLARA RDKRESDSER
LKRTAQKVDT ALKQLRRIRE YEQRLKGLEQ EVQHCSRVLG WVADALSRST LLPPGGPPPP
APSGPKD
//
