ID A0A2Y9LFW7_ENHLU Unreviewed; 300 AA.
AC A0A2Y9LFW7;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Solute carrier family 25 member 35 isoform X1 {ECO:0000313|RefSeq:XP_022380505.1};
GN Name=LOC111161215 {ECO:0000313|RefSeq:XP_022380505.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022380505.1};
RN [1] {ECO:0000313|RefSeq:XP_022380505.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022380505.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative antiporter that exchanges dicarboxylates and sulfur
CC oxoanions across the inner membrane of mitochondria.
CC {ECO:0000256|ARBA:ARBA00037259}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) +
CC sulfate(in); Xref=Rhea:RHEA:76595, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:28965; Evidence={ECO:0000256|ARBA:ARBA00035937};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR RefSeq; XP_022380505.1; XM_022524797.1.
DR AlphaFoldDB; A0A2Y9LFW7; -.
DR STRING; 391180.A0A2Y9LFW7; -.
DR KEGG; elk:111161215; -.
DR OrthoDB; 167716at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45928; RE38146P; 1.
DR PANTHER; PTHR45928:SF2; SOLUTE CARRIER FAMILY 25 MEMBER 35; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transport {ECO:0000256|RuleBase:RU000488}.
FT REPEAT 1..90
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 100..193
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 203..294
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 300 AA; 32514 MW; 7542E499B0B11192 CRC64;
MDFLMSGLAA CGACLFTNPL EVVKTRMQLQ GELRAPGTYQ RHYRNVFHAF ITIGKVDGPA
ALQKGLAPAL LYQFLMNGIR LGTYGLAEAG GYLHTAEGAL SRPRSAAAGA LAGVMGAYLG
SPIYMVKTHL QAQAASEIAV GHQYKHQGMF QALSEIGQKH GLVGLWRGAL GGLPRVIIGS
STQLCTFSST KDLITQWEIF PPQSWKVALV AAMVSGIAVV LAMTPFDVVS TRLYNQPTDA
RGKGLMYRGI LDALLQTART EGVFGMYKGI GASYFRLGPH TILSLFFWDQ LRTLYNTYTK
//
