ID   A0A2Y9LH18_ENHLU        Unreviewed;       403 AA.
AC   A0A2Y9LH18;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Nesprin-4 isoform X2 {ECO:0000313|RefSeq:XP_022380945.1};
GN   Name=LOC111161518 {ECO:0000313|RefSeq:XP_022380945.1};
OS   Enhydra lutris kenyoni (northern sea otter).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Lutrinae; Enhydra.
OX   NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022380945.1};
RN   [1] {ECO:0000313|RefSeq:XP_022380945.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022380945.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the nesprin family.
CC       {ECO:0000256|ARBA:ARBA00008619}.
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DR   RefSeq; XP_022380945.1; XM_022525237.1.
DR   AlphaFoldDB; A0A2Y9LH18; -.
DR   Proteomes; UP000248482; Unplaced.
DR   GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:InterPro.
DR   InterPro; IPR012315; KASH.
DR   InterPro; IPR030268; SYNE4.
DR   PANTHER; PTHR21640:SF1; NESPRIN-4; 1.
DR   PANTHER; PTHR21640; UNCHARACTERIZED; 1.
DR   Pfam; PF10541; KASH; 1.
DR   SMART; SM01249; KASH; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 1.
DR   PROSITE; PS51049; KASH; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00385};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TOPO_DOM        1..354
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   TRANSMEM        355..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TOPO_DOM        376..403
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT   DOMAIN          346..403
FT                   /note="KASH"
FT                   /evidence="ECO:0000259|PROSITE:PS51049"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  43127 MW;  723D4A3E224697C1 CRC64;
     MALPPPLGPR PPSEPLNHPP GAPRELDIAG FTLCPASEER LRPDQAQELG QDSLDPPQHL
     QGGMGGTEPT AGPLRLPTPT SSEDAAGGKH CEHLSSGQEV LEAEQDSLAL CLLGLGLRLR
     DLERGLGPWA SAQSRMGQLQ ALQADLRGAA ERIDALLAFG EGLAQRSEPQ ARASLEQVLR
     ALRAHRGSIF RRLWWLQAQL VSSSLVFEEA SPLDQDLEVE GDLDGPGPGE VWGPWAPSSY
     PTPAELEWDP AGDVGGLRPL WQKTAWTPGA PCELCGHRGP QGRGQGLEFS QGPHISVSPQ
     DMLMSGFSHW KHLAGQRRRS LLRKSQDKKR ASPNLQGVML EAEPGAPPPA SRHSLIFLLL
     LLFFLLVGAT LLLPPSGGSC CSSARLAGTP YLVLSYVNGP PPI
//