ID A0A2Y9LHM1_ENHLU Unreviewed; 744 AA.
AC A0A2Y9LHM1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Transducin-like enhancer protein 2 isoform X1 {ECO:0000313|RefSeq:XP_022381155.1};
GN Name=LOC111161667 {ECO:0000313|RefSeq:XP_022381155.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022381155.1};
RN [1] {ECO:0000313|RefSeq:XP_022381155.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022381155.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_022381155.1; XM_022525447.1.
DR AlphaFoldDB; A0A2Y9LHM1; -.
DR STRING; 391180.A0A2Y9LHM1; -.
DR KEGG; elk:111161667; -.
DR OrthoDB; 1333122at2759; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 17..128
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 544..585
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 586..627
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 668..699
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 172..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..52
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 215..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 744 AA; 79881 MW; F298FF2B5C6E379B CRC64;
MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS
LIGQQQLQPL SHHAPPVPLT PRPAGLVGSS ATGLLALSGA LAAQAQLAAA AKEDRAGGEA
EGPRVERAPS RSASPSPPES VVEEERPGGP GGSGKQRPED KDLSGPYESD EDKSDYNLVV
DEDQPSEPPS PATTPCGKAP MCVPARRDLV DSPASLASSL GSPLPRAKEL VLNDLPASTP
APKSCDSSPP QDASTPGPSS AGHLRQLAAK PAPCTDSVAL RSPLTLSSPF TTSFSLSSHS
ALNGDLSVPS SYVSLHLSPQ VSGSVVYGRS PMMAFECHPH LRGSSISSSL PTIPGGKPAY
SFHVSADGQM QPVPFPSDAL VGAGIPRHAR QLHTLAHGEV VCAVTISGST QHVYTGGKGC
VKVWDVGQPG AKTPVAQLDC LNRDNYIRSC KLLPDGRSLI VGGEASTLSI WDLAAPTPRI
KAELTSSAPA CYALAVSPDA KVCFSCCSDG NIVVWDLQNQ TMVRQFQGHT DGASCIDISD
YGTRLWTGGL DNTVRCWDLR EGRQLQQHDF SSQIFSLGHC PNQDWLAVGM ESSNVEVLHV
RKPEKYQLHL HESCVLALKF ASCGRWFVST GKDNLLNAWR TPYGASIFQS KESSSVLSCD
ISGNNKYIVT GSGDKKATVY EVVY
//