ID A0A2Y9LI45_DELLE Unreviewed; 528 AA.
AC A0A2Y9LI45;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Large neutral amino acids transporter small subunit 2 {ECO:0000256|ARBA:ARBA00040823};
DE AltName: Full=L-type amino acid transporter 2 {ECO:0000256|ARBA:ARBA00042153};
DE AltName: Full=Solute carrier family 7 member 8 {ECO:0000256|ARBA:ARBA00042897};
GN Name=SLC7A8 {ECO:0000313|RefSeq:XP_022409195.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409195.1};
RN [1] {ECO:0000313|RefSeq:XP_022409195.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409195.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-
CC thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015;
CC Evidence={ECO:0000256|ARBA:ARBA00036782};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71812;
CC Evidence={ECO:0000256|ARBA:ARBA00036782};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in);
CC Xref=Rhea:RHEA:71823, ChEBI:CHEBI:176514;
CC Evidence={ECO:0000256|ARBA:ARBA00036268};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71824;
CC Evidence={ECO:0000256|ARBA:ARBA00036268};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71043, ChEBI:CHEBI:57972,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036038};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71031, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036314};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-
CC methionine(out); Xref=Rhea:RHEA:71055, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:57844; Evidence={ECO:0000256|ARBA:ARBA00036858};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-
CC phenylalanine(out); Xref=Rhea:RHEA:71439, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036891};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71027, ChEBI:CHEBI:58095,
CC ChEBI:CHEBI:58359; Evidence={ECO:0000256|ARBA:ARBA00036982};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71003, ChEBI:CHEBI:57595,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036798};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) +
CC L-phenylalanine(in); Xref=Rhea:RHEA:71011, ChEBI:CHEBI:58045,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036180};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71023, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036639};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(out) + L-methionine(in) = L-leucine(in) + L-
CC methionine(out); Xref=Rhea:RHEA:71051, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:57844; Evidence={ECO:0000256|ARBA:ARBA00036218};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(out) + S-methylmercury-L-cysteine(in) = L-
CC leucine(in) + S-methylmercury-L-cysteine(out); Xref=Rhea:RHEA:71107,
CC ChEBI:CHEBI:57427, ChEBI:CHEBI:190186;
CC Evidence={ECO:0000256|ARBA:ARBA00035915};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-methionine(in) + L-phenylalanine(out) = L-methionine(out) +
CC L-phenylalanine(in); Xref=Rhea:RHEA:71039, ChEBI:CHEBI:57844,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036407};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-methionine(in) + S-methylmercury-L-cysteine(out) = L-
CC methionine(out) + S-methylmercury-L-cysteine(in);
CC Xref=Rhea:RHEA:71103, ChEBI:CHEBI:57844, ChEBI:CHEBI:190186;
CC Evidence={ECO:0000256|ARBA:ARBA00036006};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-
CC serine(out); Xref=Rhea:RHEA:71035, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00035793};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in)
CC + L-tryptophan(out); Xref=Rhea:RHEA:71007, ChEBI:CHEBI:57912,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036146};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-
CC valine(out); Xref=Rhea:RHEA:71019, ChEBI:CHEBI:57762,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036762};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-
CC phenylalanine(in) + S-methylmercury-L-cysteine(out);
CC Xref=Rhea:RHEA:71111, ChEBI:CHEBI:58095, ChEBI:CHEBI:190186;
CC Evidence={ECO:0000256|ARBA:ARBA00036087};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine(in) + L-phenylalanine(out) = glycine(out) + L-
CC phenylalanine(in); Xref=Rhea:RHEA:71047, ChEBI:CHEBI:57305,
CC ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00037022};
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC {ECO:0000256|ARBA:ARBA00007040}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022409195.1; XM_022553487.2.
DR AlphaFoldDB; A0A2Y9LI45; -.
DR STRING; 9749.A0A2Y9LI45; -.
DR Ensembl; ENSDLET00000030414; ENSDLEP00000027672; ENSDLEG00000019937.
DR KEGG; dle:111164128; -.
DR InParanoid; A0A2Y9LI45; -.
DR OrthoDB; 1103451at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031528; C:microvillus membrane; IEA:Ensembl.
DR GO; GO:0015297; F:antiporter activity; IEA:Ensembl.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:1904273; P:L-alanine import across plasma membrane; IEA:Ensembl.
DR GO; GO:1903801; P:L-leucine import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035524; P:proline transmembrane transport; IEA:Ensembl.
DR GO; GO:0015827; P:tryptophan transport; IEA:Ensembl.
DR GO; GO:0015829; P:valine transport; IEA:Ensembl.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004760; L_AA_transporter.
DR NCBIfam; TIGR00911; 2A0308; 1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF113; LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 57648 MW; 6A9FC5EAEECEABED CRC64;
MEKGARHRNN TGKNHPGGSE SEASPETGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV
SPKGVLENAG SVGLALIVWI MTGLITAVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF
LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV
RWATRVQDVF TAGKLLALGL IIVMGVVQIC KGQYFWLEPK NAFENFQEPD IGLIALAFLQ
GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN
AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK
RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYFFYG VTIAGQIVLR WKKPDIPRPI
KVSLLFPVVY LLFWAFLLVF SLWSEPVVCG TGLAIMLTGV PVYFLGVYWQ HKPRCFSKFI
ELLTLVSQKM CMVVYPKVEE DSGTEELQED MQEQRQPTAP KDKDAEEP
//