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Database: UniProt
Entry: A0A2Y9LI45_DELLE
LinkDB: A0A2Y9LI45_DELLE
Original site: A0A2Y9LI45_DELLE 
ID   A0A2Y9LI45_DELLE        Unreviewed;       528 AA.
AC   A0A2Y9LI45;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Large neutral amino acids transporter small subunit 2 {ECO:0000256|ARBA:ARBA00040823};
DE   AltName: Full=L-type amino acid transporter 2 {ECO:0000256|ARBA:ARBA00042153};
DE   AltName: Full=Solute carrier family 7 member 8 {ECO:0000256|ARBA:ARBA00042897};
GN   Name=SLC7A8 {ECO:0000313|RefSeq:XP_022409195.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409195.1};
RN   [1] {ECO:0000313|RefSeq:XP_022409195.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022409195.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-
CC         thyronine(in); Xref=Rhea:RHEA:71811, ChEBI:CHEBI:533015;
CC         Evidence={ECO:0000256|ARBA:ARBA00036782};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71812;
CC         Evidence={ECO:0000256|ARBA:ARBA00036782};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in);
CC         Xref=Rhea:RHEA:71823, ChEBI:CHEBI:176514;
CC         Evidence={ECO:0000256|ARBA:ARBA00036268};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71824;
CC         Evidence={ECO:0000256|ARBA:ARBA00036268};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71043, ChEBI:CHEBI:57972,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036038};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71031, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036314};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-
CC         methionine(out); Xref=Rhea:RHEA:71055, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:57844; Evidence={ECO:0000256|ARBA:ARBA00036858};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-
CC         phenylalanine(out); Xref=Rhea:RHEA:71439, ChEBI:CHEBI:57504,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036891};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71027, ChEBI:CHEBI:58095,
CC         ChEBI:CHEBI:58359; Evidence={ECO:0000256|ARBA:ARBA00036982};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71003, ChEBI:CHEBI:57595,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036798};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) +
CC         L-phenylalanine(in); Xref=Rhea:RHEA:71011, ChEBI:CHEBI:58045,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036180};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71023, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036639};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-leucine(out) + L-methionine(in) = L-leucine(in) + L-
CC         methionine(out); Xref=Rhea:RHEA:71051, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:57844; Evidence={ECO:0000256|ARBA:ARBA00036218};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-leucine(out) + S-methylmercury-L-cysteine(in) = L-
CC         leucine(in) + S-methylmercury-L-cysteine(out); Xref=Rhea:RHEA:71107,
CC         ChEBI:CHEBI:57427, ChEBI:CHEBI:190186;
CC         Evidence={ECO:0000256|ARBA:ARBA00035915};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-methionine(in) + L-phenylalanine(out) = L-methionine(out) +
CC         L-phenylalanine(in); Xref=Rhea:RHEA:71039, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036407};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-methionine(in) + S-methylmercury-L-cysteine(out) = L-
CC         methionine(out) + S-methylmercury-L-cysteine(in);
CC         Xref=Rhea:RHEA:71103, ChEBI:CHEBI:57844, ChEBI:CHEBI:190186;
CC         Evidence={ECO:0000256|ARBA:ARBA00036006};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-
CC         serine(out); Xref=Rhea:RHEA:71035, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00035793};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in)
CC         + L-tryptophan(out); Xref=Rhea:RHEA:71007, ChEBI:CHEBI:57912,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036146};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-phenylalanine(out) + L-valine(in) = L-phenylalanine(in) + L-
CC         valine(out); Xref=Rhea:RHEA:71019, ChEBI:CHEBI:57762,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00036762};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-
CC         phenylalanine(in) + S-methylmercury-L-cysteine(out);
CC         Xref=Rhea:RHEA:71111, ChEBI:CHEBI:58095, ChEBI:CHEBI:190186;
CC         Evidence={ECO:0000256|ARBA:ARBA00036087};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine(in) + L-phenylalanine(out) = glycine(out) + L-
CC         phenylalanine(in); Xref=Rhea:RHEA:71047, ChEBI:CHEBI:57305,
CC         ChEBI:CHEBI:58095; Evidence={ECO:0000256|ARBA:ARBA00037022};
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004554}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
CC       {ECO:0000256|ARBA:ARBA00007040}.
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DR   RefSeq; XP_022409195.1; XM_022553487.2.
DR   AlphaFoldDB; A0A2Y9LI45; -.
DR   STRING; 9749.A0A2Y9LI45; -.
DR   Ensembl; ENSDLET00000030414; ENSDLEP00000027672; ENSDLEG00000019937.
DR   KEGG; dle:111164128; -.
DR   InParanoid; A0A2Y9LI45; -.
DR   OrthoDB; 1103451at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031528; C:microvillus membrane; IEA:Ensembl.
DR   GO; GO:0015297; F:antiporter activity; IEA:Ensembl.
DR   GO; GO:0015187; F:glycine transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0015180; F:L-alanine transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0015190; F:L-leucine transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:1904273; P:L-alanine import across plasma membrane; IEA:Ensembl.
DR   GO; GO:1903801; P:L-leucine import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0035524; P:proline transmembrane transport; IEA:Ensembl.
DR   GO; GO:0015827; P:tryptophan transport; IEA:Ensembl.
DR   GO; GO:0015829; P:valine transport; IEA:Ensembl.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004760; L_AA_transporter.
DR   NCBIfam; TIGR00911; 2A0308; 1.
DR   PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR   PANTHER; PTHR11785:SF113; LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2; 1.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   PIRSF; PIRSF006060; AA_transporter; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..528
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   528 AA;  57648 MW;  6A9FC5EAEECEABED CRC64;
     MEKGARHRNN TGKNHPGGSE SEASPETGSG GGGVALKKEI GLVSACGIIV GNIIGSGIFV
     SPKGVLENAG SVGLALIVWI MTGLITAVGA LCYAELGVTI PKSGGDYSYV KDIFGGLAGF
     LRLWIAVLVI YPTNQAVIAL TFSNYVLQPL FPTCFPPESG LRLLAAICLL LLTWVNCSSV
     RWATRVQDVF TAGKLLALGL IIVMGVVQIC KGQYFWLEPK NAFENFQEPD IGLIALAFLQ
     GSFAYGGWNF LNYVTEELVD PYKNLPRAIF ISIPLVTFVY VFANVAYVTA MSPQELLASN
     AVAVTFGEKL LGVMAWIMPI SVALSTFGGV NGSLFTSSRL FFAGAREGHL PSVLAMIHVK
     RCTPIPALLF TCISTLLMLV TSDMYTLINY VGFINYFFYG VTIAGQIVLR WKKPDIPRPI
     KVSLLFPVVY LLFWAFLLVF SLWSEPVVCG TGLAIMLTGV PVYFLGVYWQ HKPRCFSKFI
     ELLTLVSQKM CMVVYPKVEE DSGTEELQED MQEQRQPTAP KDKDAEEP
//
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