ID A0A2Y9LI83_DELLE Unreviewed; 484 AA.
AC A0A2Y9LI83;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Forkhead box protein G1 {ECO:0000256|ARBA:ARBA00034868};
GN Name=FOXG1 {ECO:0000313|RefSeq:XP_022409225.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409225.1};
RN [1] {ECO:0000313|RefSeq:XP_022409225.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409225.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription repression factor which plays an important role
CC in the establishment of the regional subdivision of the developing
CC brain and in the development of the telencephalon.
CC {ECO:0000256|ARBA:ARBA00034686}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_022409225.1; XM_022553517.2.
DR AlphaFoldDB; A0A2Y9LI83; -.
DR STRING; 9749.A0A2Y9LI83; -.
DR Ensembl; ENSDLET00000026928; ENSDLEP00000024471; ENSDLEG00000017768.
DR KEGG; dle:111164140; -.
DR InParanoid; A0A2Y9LI83; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:Ensembl.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0048664; P:neuron fate determination; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0021852; P:pyramidal neuron migration to cerebral cortex; IEA:Ensembl.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
DR CDD; cd20021; FH_FOXG; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR047208; FOXG1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46617; FORKHEAD BOX PROTEIN G1; 1.
DR PANTHER; PTHR46617:SF3; FORKHEAD BOX PROTEIN G1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 176..270
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 176..270
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 31..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..110
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 51770 MW; B4383DDB5FF22958 CRC64;
MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHHPPP
PAPQPPPPPP QQQPPPPPPP ARGAPAADDD KGPQQLLLPP PPPPPPPAAA LDGAKADGLG
GKGEPGGGPG ELAPVGPDEK EKGAGAGGEE KKGAGEGGKD GEGGKEGEKK NGKYEKPPFS
YNALIMMAIR QSPEKRLTLN GIYEFIMKNF PYYRENKQGW QNSIRHNLSL NKCFVKVPRH
YDDPGKGNYW MLDPSSDDVF IGGTTGKLRR RSTTSRAKLA FKRGARLTST GLTFMDRAGS
LYWPMSPFLS LHHPRASSTL SYNGTTSAYP SHPMPYSSVL TQNSLGNNHS FSTANGLSVD
RLVNGEIPYA THHLTAAALA ASVPCGLSVP CSGTYSLNPC SVNLLAGQTS YFFPHVPHPS
MTSQSSTSMS ARAASSSTSP QAPSTLPCES LRPSLPSFTT GLSGGLSDYF THQNQGSSSN
PLIH
//
