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Database: UniProt
Entry: A0A2Y9LIR9_DELLE
LinkDB: A0A2Y9LIR9_DELLE
Original site: A0A2Y9LIR9_DELLE 
ID   A0A2Y9LIR9_DELLE        Unreviewed;      1018 AA.
AC   A0A2Y9LIR9;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN   Name=LOC111162952 {ECO:0000313|RefSeq:XP_022406982.1};
OS   Delphinapterus leucas (Beluga whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Monodontidae; Delphinapterus.
OX   NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022406982.1};
RN   [1] {ECO:0000313|RefSeq:XP_022406982.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_022406982.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Required for replication-independent chromatin assembly and
CC       for the periodic repression of histone gene transcription during the
CC       cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC   -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC       {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR   RefSeq; XP_022406982.1; XM_022551274.2.
DR   AlphaFoldDB; A0A2Y9LIR9; -.
DR   STRING; 9749.A0A2Y9LIR9; -.
DR   KEGG; dle:111162952; -.
DR   InParanoid; A0A2Y9LIR9; -.
DR   OrthoDB; 5478541at2759; -.
DR   Proteomes; UP000248483; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR031120; HIR1-like.
DR   InterPro; IPR011494; HIRA-like_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR   PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR   Pfam; PF07569; Hira; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW   ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW   Repressor {ECO:0000256|RuleBase:RU364014};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364014};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364014};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          66..98
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          127..159
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          170..201
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          764..963
FT                   /note="Protein HIRA-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07569"
FT   REGION          405..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          604..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..522
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..556
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1018 AA;  111602 MW;  99FA7DD5660F86DA CRC64;
     MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ EDDEKDENVP
     KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA TYIGPSTVFG SSGKLANVEQ
     WRCVSILRSH SGDVMDVAWS PHDAWLASCS VDNTVVIWNA VKFPEILATL RGHSGLVKGL
     TWDPVGKYIA SQADDRSLKV WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA
     HAMNNSGPTA QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS AKPSCPYCCC
     AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG SVAFLDFSQD
     ELGDPLSEEE KSRIHQSTYG KSLAIMTETQ LSTAVIENPE MLKYQRRQQQ QQLDQKGSAA
     RETGSTTSVA GVVNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSTAFFN
     SIPLSGSLAG TMLTSHSSPQ LLPLDSNTPV PFGTSKPSTE PVAATGTRPA GDSVSKDSVN
     AASAPAAPSP SILTTPSKIE PMKAFDSRFT ERSKATPGAP ALAGLTLTAM ERLKEQSLVK
     ELRPRDVLES SSDSDEKVPV AKPSSLSKRK LELEVETVEK KKKGRPRKDS RLLPMSLSVQ
     SPAALTAEKD AVCLSVPAAA LKLPMPGPQR AFTLQVSSDP SMYIEVENEV TAVGGIKLSR
     LKCSREGKEW ETVLTSRILT AAGSCDVVCV ACEKRMLSVF STCGRRLLPP ILLPSPISTL
     HCTGSYVMAL TATATLSVWD VHRQIVVVKE ESLHSILAGS DMTVSQILLT QHGIPVMNLS
     DGKAYCFNPS LSAWNLVSDK QDSLAQCADF RSSLPPQDAM LCSGPLAIVQ GRASTSSGRQ
     AARLFSVPHM VQQETTLAYL ESQVAAALTL RSSHEYRHWL LLYVRYLVNE GFEYRLREIC
     KDLLGPVHSS TGSQWESTVV GLRKRDLLKE LLPVIGQNLR FQRLFTECQE QLDILRDK
//
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