ID A0A2Y9LJK0_DELLE Unreviewed; 296 AA.
AC A0A2Y9LJK0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Myeloid differentiation primary response protein MyD88 {ECO:0000256|ARBA:ARBA00021472, ECO:0000256|PIRNR:PIRNR037756};
GN Name=MYD88 {ECO:0000313|RefSeq:XP_022409680.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409680.1};
RN [1] {ECO:0000313|RefSeq:XP_022409680.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409680.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC receptor signaling pathway in the innate immune response.
CC {ECO:0000256|PIRNR:PIRNR037756}.
CC -!- SUBUNIT: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2,
CC TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.
CC {ECO:0000256|PIRNR:PIRNR037756}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037756}.
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DR RefSeq; XP_022409680.1; XM_022553972.2.
DR AlphaFoldDB; A0A2Y9LJK0; -.
DR STRING; 9749.A0A2Y9LJK0; -.
DR Ensembl; ENSDLET00000020255; ENSDLEP00000018362; ENSDLEG00000013408.
DR KEGG; dle:111164350; -.
DR InParanoid; A0A2Y9LJK0; -.
DR OrthoDB; 2964088at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:Ensembl.
DR GO; GO:0070976; F:TIR domain binding; IEA:Ensembl.
DR GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0038172; P:interleukin-33-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; IEA:Ensembl.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; MYD88; 1.
DR PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037756; MyD88; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR037756};
KW Immunity {ECO:0000256|PIRNR:PIRNR037756};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037756};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483}.
FT DOMAIN 32..109
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 159..293
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0000256|PIRSR:PIRSR037756-1"
SQ SEQUENCE 296 AA; 33366 MW; D12358801058B723 CRC64;
MAEGGPDAGS APPTPSMSSL PLAALNVRVR RRLSLFLNLR AHVAADWTAL AEEMGFEYLE
IRRLETHADP TGSLLDDWQG RPGASVGRLL ELLGKLGRDD LLMELGPSIE EDCQKYILKQ
QQEASEKPLQ VDSVDSSIPR TRDPAGITIC DDPLGQMPEC FDAFICYCPS DIQFVQEMIR
ELEQTNHRLK LCVSDRDVLP GTCIWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA
LSLSPGAHQK RLIPIKYKSM KKEFPSILRF ITICDYTNPC TKSWFWTRLA KALSLP
//
