ID A0A2Y9LJS8_DELLE Unreviewed; 803 AA.
AC A0A2Y9LJS8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Volume-regulated anion channel subunit LRRC8B {ECO:0000313|RefSeq:XP_022409010.1, ECO:0000313|RefSeq:XP_022409011.1};
GN Name=LRRC8B {ECO:0000313|RefSeq:XP_022409010.1,
GN ECO:0000313|RefSeq:XP_022409011.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409011.1};
RN [1] {ECO:0000313|RefSeq:XP_022409010.1, ECO:0000313|RefSeq:XP_022409011.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409010.1,
RC ECO:0000313|RefSeq:XP_022409011.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) = chloride(out); Xref=Rhea:RHEA:29823,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00024167};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=iodide(out) = iodide(in); Xref=Rhea:RHEA:66324,
CC ChEBI:CHEBI:16382; Evidence={ECO:0000256|ARBA:ARBA00024145};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=taurine(out) = taurine(in); Xref=Rhea:RHEA:66328,
CC ChEBI:CHEBI:507393; Evidence={ECO:0000256|ARBA:ARBA00024158};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LRRC8 family.
CC {ECO:0000256|ARBA:ARBA00010471}.
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DR RefSeq; XP_022409010.1; XM_022553302.2.
DR RefSeq; XP_022409011.1; XM_022553303.2.
DR STRING; 9749.A0A2Y9LJS8; -.
DR Ensembl; ENSDLET00000026699; ENSDLEP00000024266; ENSDLEG00000017609.
DR KEGG; dle:111164022; -.
DR OrthoDB; 55205at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005225; F:volume-sensitive anion channel activity; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR021040; LRRC8_Pannexin-like.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF36; LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT B; 1.
DR Pfam; PF13306; LRR_5; 2.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF12534; Pannexin_like; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..334
FT /note="LRRC8 pannexin-like TM region"
FT /evidence="ECO:0000259|Pfam:PF12534"
SQ SEQUENCE 803 AA; 92283 MW; 7AB5BE7A3C788CAA CRC64;
MITLTELKCL ADAQSSYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS RVLCCLPCKV
EFDNHCAVPW DILKASVNTS SDPGTPLPLP LRIQNDLHRQ QYSYIDAVCY EKQLHWFAKF
FPYLVLLHTL IFAACSNFWL HYPSTSSRLE HFVAILHKCF DSPWTTRALS ETVAEQSVRP
LTLSKSKVLL SSSGCSADVD SNKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK
VKRFRMHVEQ KDIIYRVYLK QIIVKVILFV LIITYVPYFL TYITLEIDCS VDVQAFTGYK
RYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLWS SLKQYSFEAL REKSNYSDIP
DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN LNNEWTVEKL KSKLVKNSQD
KIELHLFMLN GLPDNVFELT EIEVLSLELI PEVKLPSAVS QLVNLKELHV YHSSLVVDHP
ALAFLEENLK ILRLKFTEMG KIPRWVFHLK NLKELYLSGC VLPEQVSTMQ LEGFQDLKNL
RTLYLKSSIS RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI
PHSIFSLNNL HELNLKENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA QIGALSNLEQ
LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY LSNLQYFAVT NNNIEMLPDG
LFQCKKLQCL LLGKNSLMSL SPHVGELSNL THLELIGNYL ETLPPELEGC QSLKRSCLIV
EENLLNTLPP PVTERLQTCL DKC
//
