ID A0A2Y9LK49_DELLE Unreviewed; 776 AA.
AC A0A2Y9LK49;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho guanine nucleotide exchange factor 6 isoform X2 {ECO:0000313|RefSeq:XP_022410034.1};
GN Name=ARHGEF6 {ECO:0000313|RefSeq:XP_022410034.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410034.1};
RN [1] {ECO:0000313|RefSeq:XP_022410034.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410034.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR RefSeq; XP_022410034.1; XM_022554326.2.
DR AlphaFoldDB; A0A2Y9LK49; -.
DR Ensembl; ENSDLET00000001820; ENSDLEP00000001584; ENSDLEG00000001336.
DR Ensembl; ENSDLET00000001913; ENSDLEP00000001673; ENSDLEG00000001336.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR CDD; cd21265; CH_alphaPIX; 1.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 160..219
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 241..421
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 443..548
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 115..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 116..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 776 AA; 87547 MW; 5E02D4D4E71085EF CRC64;
MNPEERIVTW LISLGVLDSP KKTICDPEEF LKSSLKNGVV LCKLINRLRP GSIEKYCLEP
QTEADCTNNV NDFLKGCAAL QVEVFDPDDL HAGVNFSKVL STLLAVNKAT EDQLSERPCG
RSSSLSAANS SQTNPQGAVS STAPGLQRQS KPVEMTENGS HQLIVKARFN FKQTNEDELS
VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETTPLTKN
YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EFTSLLGNFE EVCTFQQTLC
QALEECSKFP ENQHKVGGCL LNLMPHFKSM YLAYCANHPS AVNVLTQHSD DLERFMENQG
ASSPGILILT TSLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIIA FKTLMGQCQD
LRKRKQLELQ ILSEPIQAWE GEDIKTLGNV IFMSQVMVQY GTCEEKEERY LMLFSSVLIM
LSASPRMSGF IYQGKIPIAG MVVTRLDEIE GNDYTFEITG NIVERTVVHC GNNQDFQDWL
EHLYRLIRGP TSCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL
RPSAALGYKE RMSYILKESG KSPKTMKKFL HKRKTERKPS EEEYVIRKST AALEEDAQIL
KVIEAYCTSA NFQQGHSSSA RKDSVPQVLL PEEEKLIIEE TRSNGQTIIE EKSLVDTVYA
LKDEVKELKQ ENKRMKQCLE EELKSRRDLE KLVRRLLKQT DECVRAESSS KTSILP
//
