ID A0A2Y9LKG2_DELLE Unreviewed; 323 AA.
AC A0A2Y9LKG2;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Four and a half LIM domains protein 1 isoform X2 {ECO:0000313|RefSeq:XP_022409965.1, ECO:0000313|RefSeq:XP_022409966.1};
GN Name=FHL1 {ECO:0000313|RefSeq:XP_022409965.1,
GN ECO:0000313|RefSeq:XP_022409966.1, ECO:0000313|RefSeq:XP_022409967.1,
GN ECO:0000313|RefSeq:XP_022409968.1, ECO:0000313|RefSeq:XP_022409969.1,
GN ECO:0000313|RefSeq:XP_022409970.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409970.1};
RN [1] {ECO:0000313|RefSeq:XP_022409965.1, ECO:0000313|RefSeq:XP_022409966.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409965.1,
RC ECO:0000313|RefSeq:XP_022409966.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022409965.1; XM_022554257.1.
DR RefSeq; XP_022409966.1; XM_022554258.2.
DR RefSeq; XP_022409967.1; XM_022554259.2.
DR RefSeq; XP_022409968.1; XM_022554260.1.
DR RefSeq; XP_022409969.1; XM_022554261.1.
DR RefSeq; XP_022409970.1; XM_022554262.2.
DR Ensembl; ENSDLET00000002127; ENSDLEP00000001866; ENSDLEG00000001531.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0043268; P:positive regulation of potassium ion transport; IEA:Ensembl.
DR GO; GO:0003254; P:regulation of membrane depolarization; IEA:Ensembl.
DR CDD; cd09344; LIM1_FHL1; 1.
DR CDD; cd09424; LIM2_FHL1; 1.
DR CDD; cd09429; LIM3_FHL1; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR042997; Fhl1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR47029; FOUR AND A HALF LIM DOMAINS PROTEIN 1; 1.
DR PANTHER; PTHR47029:SF4; FOUR AND A HALF LIM DOMAINS PROTEIN 1; 1.
DR Pfam; PF00412; LIM; 3.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 4.
DR PROSITE; PS00478; LIM_DOMAIN_1; 3.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 38..98
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 99..160
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 161..219
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
SQ SEQUENCE 323 AA; 36315 MW; FF1FF8A173C6CBB4 CRC64;
MAEKFDCHYC RDNLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD SKEVHYKNRY
WHDTCFRCAK CLRSLANETF VAKDNKILCN KCTTREDSPK CKGCFKPIVA GDQNVEYKGT
VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC VTCHEAKFAK HCVKCNKAIT SGGITYQDQP
WHAECFVCVT CSKKLAGQRF TAVEDQYYCV DCYKNFVAKK CAGCKNPITG KRTVSRVSHP
VSKARKPPVC HGKRLPLTLF PSANLRGRHP GGERTCPSWV VVLYRKNRSL AAPRGPGLVK
APVWWPMKDN PGTTTASTAK NAP
//
