ID A0A2Y9LKQ1_ENHLU Unreviewed; 188 AA.
AC A0A2Y9LKQ1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Apoptosis-associated speck-like protein containing a CARD isoform X2 {ECO:0000313|RefSeq:XP_022382300.1};
GN Name=LOC111162289 {ECO:0000313|RefSeq:XP_022382300.1};
OS Enhydra lutris kenyoni (northern sea otter).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Lutrinae; Enhydra.
OX NCBI_TaxID=391180 {ECO:0000313|Proteomes:UP000248482, ECO:0000313|RefSeq:XP_022382300.1};
RN [1] {ECO:0000313|RefSeq:XP_022382300.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022382300.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Inflammasome {ECO:0000256|ARBA:ARBA00004110}.
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DR RefSeq; XP_022382300.1; XM_022526592.1.
DR AlphaFoldDB; A0A2Y9LKQ1; -.
DR Proteomes; UP000248482; Unplaced.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR PANTHER; PTHR46985:SF2; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD; 1.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50824; DAPIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023233};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Reference proteome {ECO:0000313|Proteomes:UP000248482}.
FT DOMAIN 1..91
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 100..188
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
SQ SEQUENCE 188 AA; 21051 MW; C3D8C01DB9DCA02C CRC64;
MGCTRDAILD ALENLTADEF KKFKLKLLSV PLREGYGRIP RGTLMSMDAM DLTDKLVSSY
LEEYSAELTM IVLREIGMQE IAEHLQARTH PGELAQGLSV LPTAPHFVDQ HRAALITRVT
DVEAVLDALY GKVLSDGQYE AVRAESTNTM KMRKLLSFAP AWDKTCKDQL LQALRNTHPY
LVADLEKS
//
