ID A0A2Y9LMH8_DELLE Unreviewed; 525 AA.
AC A0A2Y9LMH8;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Neuropilin and tolloid-like protein 2 isoform X1 {ECO:0000313|RefSeq:XP_022410894.1};
GN Name=NETO2 {ECO:0000313|RefSeq:XP_022410894.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022410894.1};
RN [1] {ECO:0000313|RefSeq:XP_022410894.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022410894.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_022410894.1; XM_022555186.1.
DR AlphaFoldDB; A0A2Y9LMH8; -.
DR STRING; 9749.A0A2Y9LMH8; -.
DR KEGG; dle:111165030; -.
DR InParanoid; A0A2Y9LMH8; -.
DR OrthoDB; 3024898at2759; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF26; NEUROPILIN AND TOLLOID-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..525
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016094805"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..159
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 177..292
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 45..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 297..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 304..322
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 316..331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 525 AA; 59242 MW; 6693415A417FA7C9 CRC64;
MALEQLCSVL KVLLITILVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP
NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDNLEVRDG PFGFSPLVDR
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE
LSGADGIIRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA
VYDGSSSIEN LKAKFCSTVA NDVMLKTGVG VIRMWADEGS RLSRFRMLFT SFVEPPCTGS
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGLF EQITKTHGTI IGITSGIVLV
LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEMSA DLADLSEELD
SYQKARCSST ASRCIHDHHC GSQAPSIKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK
SSYTFKQAHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF
//
