ID A0A2Y9LNP5_DELLE Unreviewed; 1531 AA.
AC A0A2Y9LNP5;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRM {ECO:0000313|RefSeq:XP_022406898.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022406898.1};
RN [1] {ECO:0000313|RefSeq:XP_022406898.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022406898.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_022406898.1; XM_022551190.2.
DR STRING; 9749.A0A2Y9LNP5; -.
DR KEGG; dle:111162901; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14633; R-PTPc-M-1; 1.
DR CDD; cd14635; R-PTPc-M-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045911; R-PTP-mu_cat_rpt1.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF12; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, M; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_022406898.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 809..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..225
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 227..318
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 325..420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 423..521
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 523..628
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 979..1233
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1150..1224
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1265..1527
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1441..1518
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 782..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1531 AA; 171783 MW; F88DCE5BA5B2BE65 CRC64;
MVLVLAVHPP LLAALEAKLP AALRPRAHPV PPGAARRALS TMGRLGTCLA TLTGLLLTAA
GDTFSGGCLF DEPYSTCGYS QAEDHDFNWE QVNTLTKPTS DPWMPSGSFM LVNTSGRSEG
QRAHLLLPQL KENDTHCIDF HYFVSSKSNS APGLLNVYVK VNNGPLGNPI WNISGDPNRT
WNRAELAIST FWPNFYQVIF EVVTSGHQGY LAIDEVKVLG HPCTRTPHFL RIQNVEVNAG
QFAAFQCSAI GRTVAGDRLW LQGIDVRDAP LKEIKVTSSR RFIASFNVMN TTKRDAGKYR
CMIRTDGGVG LSNYAELVVK EPPVPIAPPQ LASVGATYLW IQLNANSING DGPIVAREVE
YCTASGSWSD RQPVDSTSYK IGHLDPDTEY EISVLLTRPG EGGTGSPGPA LRTRTKCADP
MRGPRKLEVV EVKSRQITLR WEPFGYNVTR CHSYNLTVHY CYKVGGQEQV REEVSWDTDN
SHPQHTITNL SPYTNVSVKL ILMNPEGRKE SQELVVQTDE DLPGAVLTES IQGSTFEEKI
FLQWREPIQT YGVITLYEIT YKAVSSFDPE IDLSNQSGRV SKLGNETHFL FFGLYPGTTY
SFTIRASTAK GFGPPATNQF TTKISAPSMP AYELETPLNQ TDNTVTVLLK PAHSRGAPVS
VYQIVVEEER PRRAKKTTEI LKCYPVPIHF QNASLLNSQY YFAAEFPANS LQSAQPFTIG
DNKTYSGYWN TPLLPHKSYR IYFQAASRAN GETKIDCVQV ATKAAIIVTQ LTTPHIRIAP
AAGDDQLTGA ATPKPVPEPE KQTDHTVKIA GVIAGILLFV IIFLGVVLVM KKRKLARKRK
ETMSSTRQEM TVMVSSMDKS YAEQGTSCDE AFSFMDTHNL NGRSVSSPSS FTMKTNTLST
SVPNSYYPDP FVPTAILVPI NDETHTMASD TSSLVQPHTY KKREPADVPY QTGQLHPAIR
VADLLQHITQ MKCAEGYGFK EEYESFFEGQ SAPWDSAKKD ENRMKNRYGN IIAYDHSRVR
LQTIEGDNSS DYINGNYIDG YHRPNHYIAT QGPMQETIYD FWRMVWHENT ASIIMVTNLV
EVGRVKCCKY WPDDTEIYKD IKVTLIETEL LAEYVIRTFA VEKRGVHEIR EIRQFHFTGW
PDHGVPYHAT GLLGFVRQVK SKSPPNAGPL VVHCSAGAGR TGCFIVIDIM LDMAEREGVV
DIYNCVRELR SRRVNMVQTE EQYVFIHDAI LEACLCGDTS VPASQVRSLY YDMNKLDPQT
NSSQIKEEFR TLNMVTPTLR VEDCSIALLP RNHEKNRCMD ILPPDRCLPF LITLDGESSN
YINAALMDSY KQPSAFIVTQ HPLPNTVKDF WRLVLDYHCT SVVMLNDVDP AQLCPQYWPE
NGVHRHGPIQ VEFVSADLEE DIISRIFRIY NAARPQDGYR MVQQFQFLGW PMYRDTPVSK
RSFLKLIRQV DKWQEEYNGG EGRTVVHCLN GGGRSGTFCA ISIVCEMLRH QRTVDVFHAV
KTLRNNKPNM VDLLDQYKFC YEVALEYLNA G
//
