ID A0A2Y9LP75_DELLE Unreviewed; 3800 AA.
AC A0A2Y9LP75;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Lysosomal-trafficking regulator isoform X5 {ECO:0000313|RefSeq:XP_022408847.1};
GN Name=LYST {ECO:0000313|RefSeq:XP_022408847.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022408847.1};
RN [1] {ECO:0000313|RefSeq:XP_022408847.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022408847.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_022408847.1; XM_022553139.2.
DR Ensembl; ENSDLET00000030021; ENSDLEP00000027314; ENSDLEG00000019492.
DR Proteomes; UP000248483; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3008..3114
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3119..3421
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3611..3645
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 143..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3800 AA; 428436 MW; 19191223CE2A4D02 CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQRVGAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQL EKATDFNLPF SADIILTKEK NSSSQRSTQE
KLYLEGSAPA GQVSAKVNVF QQSRRQRKTT HRYSVRDARK TQLSTSDSEV NSDDKSIVMT
KHRRSHLLQH FVTQSPKEDH LTAKLDHLST KEQTPPDTMA LENSREKIPR QESNTDILSE
PAALSIISHM NNSPFDLCHV LLSLLEKVCK FDITLNHNSA LAASVVPTLT EFLAGFGDCC
NLSDNLENRM VSAGWTEEPV ALIQRMLFRT VLHLMSVDIS MAEMMPESLR KNLTELLRAA
LKIRTCLEKQ PDPFAPRQKK TLQEVQEDFV FSKYRHRALL LPELLEGVLQ ILICCLQSAA
SNPFFFSQAM DLVQEFIQHH GFHLLETAVL QMEWLVVRDG VPPEASEHLK ALINSVMKIM
STVKKVKSEQ LHHSMCTRKR HRRCEYSHLM HHHRDLSGLL VSAFKNQVSK NPFEETADGD
VYYPERCCCI AVCAHQCLRL LQQASLSSTC VQILLGVQNI GICCCMDPKS VIIPLLYAFK
SPALKNCRQH ILNILNKLIL DQLGGAEIPQ KTKKAACNIC TVDSDQLAKL EETLQGNVCD
AEPSSGLSSP SYRFQGILPS SGSEDLLWKW DALEAYQSFV FEEDRLCSVQ IASHISSLIQ
KGNIVVQWKL YNYIFNPVLQ RGVELAHHCQ QLDITSAQTH VCSHHDQCLP QEVVQIYLKT
LPTLLKSRVI RDLFLSCNGV NQIIELNYLD GIRNHSLKAF ETLIISLGQQ QKDSSIPGID
GTDLEQKELS SLNVSTLYNQ QAYSDSQSLS KFYARLKDAY PKKRKSVTQD VYINTINLFL
CVAFLCVSKE AESDRESAND SEDTSGYDST ASEPLQHMLP CLSLESLVLP SPKHMHQAAD
IWSMCHWIYM LSPVFQKQFY RLGGFRVCHK LIFMIIQELF RSPEEEHGRK EGDINVEENQ
DLHRPSQSEV TVKEDLLSLT VKSDPTPSEL GSLKKSADSS GKLESQPISS MNVEHIPAAE
AAPEEAKVFT NRESETSLQG IRLLEALLAI CLHGTRASQQ KMELELPNQN LSVENILLEM
RSHLSKSKVI ETELAKPLFD ALLRVALGNH SADFEHDDAM TEKSHQSEEE LSSQPGDFSE
EAEDSQCCSI KLLVEEEGYE ADTESNPEDS ETWDDGVDLK PEVESFSASS SPNDLLENLT
QGEIIYPEIC TLELNLLSAG KAKLDVLSHV FESFLKIIRQ KEKNIFLLMQ QGTVKNLLGG
FLSILTQTDS DFQACQRVLV DLLVSLMSSR TCSEELTLLL RIFLEKSPCT EILLLGILKI
VESDITMSPS QYLTFPLLHT PNLSNGVSSF SQKCPAILNS KAMGLLRRAR VSRSKKEGDS
DSFPQQLLSS WHVAPIHLPL LGQNCWPHLS EGFSVSLWFN VERIHEAEST TEKGKKTKKR
NKSLILLDSN FGGTEHNRPE GAEYVSPGER LIEEGCIHMI SLGSKALMIQ VWADPHSGTF
IFRVCMDSND DTKAVLLAQV ESQENIFLPS KWQHLVLTYL QQPQGKKNIH GKISIWVSGQ
RKPDVTLDFM LPRKTSLSSD SNKTFCMIGH CLSSQEEFLQ LAGKWDLGNL LLFNGAKIGS
QEAFYLYACG PNHTSIMPCK YGKPVNDYSK YINKDILQCE QIRELFMTNK DVDIGLLIEN
LAVVYTACCP AQYTVYEPVI RLKGQMKTQL SQRPFSSKEV HSTLLEPYHL KNLRPTECKT
LQGILHEIGG TGIFVFLFAR VVELSICEET QALALRIILS LIKYNQQRMH ELENCNGLSM
IHQVLIKQKC IVGFHILKTL LEGCCGEDII HINENGEFKL DAESNAIIQD VKLLEELLLD
WRIWNKAEQG VWETLLAALE VLLRADHQQQ MFNIKQLLKA RVVHHFLLTC QVLQEHKEGQ
LTSMPREVCR SFVKIIAEVL GSPPDLELLA AVFSFLLAAH PPTNTYVCHN PAGFYFSLHI
DGKIFQEKVQ SIMYLRHSSS GGKSVTSPGF MVISPCGFTA SPPEGNNSSS TVPQQMTASM
LRSRSLPAFP TSSPQIQPRK LTGSLGCSID KLQSVVGNDV ASQPEKWSPR GSSEMLKKGK
EDAFVSSCES AKTVCEMEAV LSAHASVSGV PKGTSGLPVV KVDQKEVGTE PRSDDDSLGD
EFCPRRPDYL KGLASFQRSH STIASLGLAF PSQNGSAAVG RWPSLVDRNT EDWENFAFSL
RYEPNHNRTT SAHSVTEDCL VPVCCGLYEL LSGVLLILPD VMLEDVMDRL IQADTLLVLV
NHPSPAVQQG VIKLLDAYFN RASKEQKDKF LKNRGFSLLA NQLYLHRGTQ ELLECFIEMF
FGRHAGLDEE FDLEDVKNMG LFQKWSVIPI LGLIETSLYD NVLLHNALLL LLQILNSCSK
VADMLLDNGL LYVLCNTVAA LNGLEKNVPL NEYRLLACDL QQLFIAVTIH ACSSSGSQYF
RVIEDLIVLL GYLQNSKSKR TQNMAVALQY RVLQAAMEFI RTTANHDSEK LTDSSQSPSA
PHHAIFQKRK SIAGPRKFPL AQTDSLLMKM RSVASDELHM MMQRRMSQEN PAQATETELA
QRLQRLTILA VNRIIYQEFN PDIIDILSTP ENAPQSKTSV SQAEISEESI YHEQPAFNPF
QKEMFTYLVE GFKVSTSSSK ASGSRQQWAK ILWSCKETFR MQLGRLLVHI LSPAHPSQER
KQIFEIVREP NHQEILRDCL SPSLQHGAKL VLYLSELIHN HEDELTEEEL DTAELLMNAL
KLCGHKCIPP SASTKSDLIK VIKEEQKKYE TEEHVNKANW QKTVNNNQQS LFQRLDSKSK
DISKIAADIT QAVSLSQGIE RKKVIQHIRG MYKVDLSASR HWQELIQQLT HDRAVWYDPI
YYPTSWQLDP TEGPNRERRR LQRCYLTIPN KYLLRDRQKS EDVVKPPLSY LFEDKTHSSF
SSTVKDKAAS ESIRVNRRCI SVAPSRETAG ELLLGKCGMY FVEDNASDTV ESSSLQGELE
PASFSWTYEE IKEVHKRWWQ LRDNAVEIFL TNGRTLLLAF DNTKVRDDVY HNILTNNLPN
LLEYGNITAL TNLWYTGQIT NFEYLTHLNK HAGRSFNDLM QYPVFPFILA DYVSETLDLS
DPSVYRNLSK PIAVQYKEKE DRYVDTYKYL EEEYRKGARE DDPMPPVQPY HYGSHYSNSG
TVLHFLVRMP PFTKMFLAYQ DQSFDIPDRT FHSTNTTWRL SSFESMTDVK ELIPEFFYLP
EFLVNREGFD FGVRQNGERV NHVNLPPWAR NDPRLFILIH RQALESDYVS QNICQWIDLV
FGYKQKGKAS VQAINVFHPA TYFGMDVSAV EDPVQRRALE TMIKTYGQTP RQLFQSAHAS
RPGSKLNIEG ELPAAVGLLV QFAFRETREQ VKEIPYPSPL SWIKGLKWGE YVGSPSAPVP
VVCFSQPHGE RFGSLQALPT KAICGLSQNF CLLMTYSKEQ GVRSMNSTDI QWSAILSWGY
ADNILRLKSK QSEPPINFIQ GSQQYQVTSC AWVPDSCQLF TGSKCGVITA YTNRFMSGTP
SEIEMESQIH LYGHTEEITS LFVCKPYSIM ISVSRDGTCI IWDLNRLCYV QSLAGHKSPV
TAVSASETTG DIATVCDSAG GGSDLRLWTV NGDLVGHVHC REIICSMAFS NQPEGISINV
IAGGLENGIV RLWSTWDLKP VREITFPKSN KPIVSLTFSC DGHHLYTANS DGTVIAWCRK
DQQRLKQPMF YSFLSSYAAG
//
