ID A0A2Y9LPM0_DELLE Unreviewed; 429 AA.
AC A0A2Y9LPM0;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sorting nexin-7 isoform X4 {ECO:0000313|RefSeq:XP_022409017.1};
GN Name=SNX7 {ECO:0000313|RefSeq:XP_022409017.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022409017.1};
RN [1] {ECO:0000313|RefSeq:XP_022409017.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022409017.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_022409017.1; XM_022553309.1.
DR AlphaFoldDB; A0A2Y9LPM0; -.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07666; BAR_SNX7; 1.
DR CDD; cd07284; PX_SNX7; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR042131; BAR_SNX7.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR042130; PX_SNX7.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR PANTHER; PTHR45949:SF3; SORTING NEXIN-7; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 94..215
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 48776 MW; 1006C1B30AECA0D3 CRC64;
MEGECRAPQA RSSGLPAGGG GGESPGGDAP LPGSSGSSAL LQAEVLDLDE DEDDLEVFSK
DASLMDMNSF SPVMPTSPLS MINQVKFEDE PDLKDLFITV DEPESHVTTI ETFITYRIIT
KTSRGEFDSS EFEVRRRYQD FLWLKERLEE AHPTLIIPPL PEKFIVKGMV ERFNDDFIET
RRKALHKFLN RIADHPTLTF NEDFKVFLTA QAWELSSHKK QGPGLLSRMG QTVRAVALSM
RGVKSRPEEF MEMNNFIEIF SQKINLIDKI SQRIYKEERE YFDEMKEYGP IHILWSASEE
DLADTLKGVA SCIDRCCKAT EKRMSGLSEA LLPVVHEYVL YSEMLMGVMK RRDQIQAELD
SKVEALTSKK ADTDLLTEEI GKLEDKVECA NNALKADWER WKQNMQNDIK SAFTDMAEEN
IHSYEQVLG
//
