ID A0A2Y9LRV1_DELLE Unreviewed; 526 AA.
AC A0A2Y9LRV1;
DT 12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT 12-SEP-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Chordin-like protein 1 isoform X2 {ECO:0000313|RefSeq:XP_022412439.1};
GN Name=CHRDL1 {ECO:0000313|RefSeq:XP_022412439.1};
OS Delphinapterus leucas (Beluga whale).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC Monodontidae; Delphinapterus.
OX NCBI_TaxID=9749 {ECO:0000313|Proteomes:UP000248483, ECO:0000313|RefSeq:XP_022412439.1};
RN [1] {ECO:0000313|RefSeq:XP_022412439.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_022412439.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_022412439.1; XM_022556731.2.
DR AlphaFoldDB; A0A2Y9LRV1; -.
DR Ensembl; ENSDLET00000012280; ENSDLEP00000011125; ENSDLEG00000008053.
DR Proteomes; UP000248483; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0097113; P:AMPA glutamate receptor clustering; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0000578; P:embryonic axis specification; IEA:Ensembl.
DR GO; GO:0098976; P:excitatory chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0048167; P:regulation of synaptic plasticity; IEA:Ensembl.
DR GO; GO:0060074; P:synapse maturation; IEA:Ensembl.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR045717; CHRDL1/2.
DR InterPro; IPR045716; CHRDL_1/2_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46303:SF2; CHORDIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR46303; VWFC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF19548; CHRDL_1_2_C; 1.
DR Pfam; PF00093; VWC; 3.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000248483};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 104..169
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 182..248
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 327..392
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 270..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 59692 MW; 4985E6D015BC3086 CRC64;
MFFLPPTFES PLPPRAHSSS RHNLRVLVLG GAPRGARSAC TRGRRRRPVA SLSTQGPESF
KLPFAVARMR KKWKMGGMRY IFSLLLFFLF LEGSKAEQVK HSETYCVFQD KKYRVGERWH
PYLEPYGLVY CVNCICSENG NVLCSRVRCP SLHCLSPVHI PHLCCPRCPD SLPPANNKVT
SKSCEYNGTT YQHGELFMAE GLFQNRQPNQ CTQCSCSEGN VYCGLKTCPK LTCAFPVSVP
DSCCRVCRGD GELSWEHSDG DIVRQPANRE ARHSYHRSHY DPPPSRQAGG LPRFPGARSH
RGALMDSQQA SGTIVQIVIN NKHKHGQVCV SNGKTYSHGE SWHPNLRAFG IVECVLCTCN
VTKQECKKIH CPSRYPCKYP QKIDGKCCKV CPGKKAKEEL PGQSFDSKGY FCGEETMPVY
ESVFMEDGET TRKIALETER PPQVEVHVWT IRKGILQHFH IEKISKRMFE ELHHFKLVTR
TTMSQWKIFT EGEAQISQMC SSRVCRTELE DLVKVLYLER SEKGHC
//
